Summary

We have a great opportunity for a talented Scientist to join our Animal Genetic Technologies department and work in a South San Francisco-based lab that develops and uses state-of-the-art technology for genome manipulation in vivo. In a highly collaborative environment, the candidate will develop and use genome editing technology (including CRISPR) in combination with classic mouse genetics approaches to enable identification of novel modifiers of disease and validation of new targets for therapeutic intervention. The department of Animal Genetic Technologies broadly focuses on creation and genetic analysis of animal models to enable target discovery and validation. The Warming lab works closely with our animal model generation group as well as colleagues across therapeutic areas and across the Genentech research community.

Job description

The Opportunity

We have a great opportunity for a talented Scientist to join our Animal Genetic Technologies department and work in a South San Francisco-based lab that develops and uses state-of-the-art technology for genome manipulation in vivo. In a highly collaborative environment, the candidate will develop and use genome editing technology (including CRISPR) in combination with classic mouse genetics approaches to enable identification of novel modifiers of disease and validation of new targets for therapeutic intervention. The department of Animal Genetic Technologies broadly focuses on creation and genetic analysis of animal models to enable target discovery and validation. The Warming lab works closely with our animal model generation group as well as colleagues across therapeutic areas and across the Genentech research community.

Who You Are

Ph.D. degree, or equivalent, in genetics and/or molecular biology, with relevant postdoctoral experience
Hands-on experience, with a published track record, working with the mouse as a model system
The candidate should have solid molecular biology skills and a strong publication record in a relevant field such as model organism genetics, stem cells, genome editing, and/or synthetic Biology
Hands-on experience with relevant techniques, including CRISPR, NGS-based technologies (RNA-seq, ChIP-seq, scRNA-Seq, Long-Read sequencing, etc.), microscopy, flow cytometry and imaging
Exceptional organizational and communication skills, the ability to work both independently and cooperatively in a fast-paced team environment
A strong interest in technology development and a drive to explore the molecular basis of disease using in vivo models, genetics, and the latest genome editing/engineering technologies

Preferred

Basic hands-on experience with bioinformatics workflows and computational sequence analysis pipelines.
Hands-on proficiency with viral vector platforms, specifically Adeno-Associated Virus (AAV) and lentiviral technologies.
3+ years of post-PhD or biotechnology/pharmaceutical industry experience.

Requirements

Ph.D. degree, or equivalent, in genetics and/or molecular biology, with relevant postdoctoral experience
Hands-on experience, with a published track record, working with the mouse as a model system
Solid molecular biology skills and a strong publication record in a relevant field such as model organism genetics, stem cells, genome editing, and/or synthetic Biology
Hands-on experience with relevant techniques, including CRISPR, NGS-based technologies (RNA-seq, ChIP-seq, scRNA-Seq, Long-Read sequencing, etc.), microscopy, flow cytometry and imaging
Exceptional organizational and communication skills, the ability to work both independently and cooperatively in a fast-paced team environment
A strong interest in technology development and a drive to explore the molecular basis of disease using in vivo models, genetics, and the latest genome editing/engineering technologies
Basic hands-on experience with bioinformatics workflows and computational sequence analysis pipelines
Hands-on proficiency with viral vector platforms, specifically Adeno-Associated Virus (AAV) and lentiviral technologies
3+ years of post-PhD or biotechnology/pharmaceutical industry experience

Benefits

Relocation benefits
Discretionary annual bonus

Company overview

Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.