Scientist 3, Lung Biology & Inflammation
Roche
Summary
The Department of Immunology at Genentech is seeking a driven Scientist with deep expertise in lung biology and immunology to uncover novel therapeutic targets for respiratory diseases. In this role, you will lead research projects investigating the cellular and molecular mechanisms underlying the lung's response to injury, chronic inflammation, and repair.
Job description
The Opportunity
The Department of Immunology at Genentech is seeking a driven Scientist with deep expertise in lung biology and immunology to uncover novel therapeutic targets for respiratory diseases. In this role, you will lead research projects investigating the cellular and molecular mechanisms underlying the lung's response to injury, chronic inflammation, and repair.
- Lead projects investigating cellular and molecular mechanisms underlying lung injury, chronic inflammation, and tissue repair.
- Advance novel research-stage programs into early clinical development by generating robust proof-of-concept data.
- Utilize state-of-the-art technologies, including in vitro and in vivo models, to evaluate novel molecules and targeted delivery systems.
- Dissect the pathogenesis of inflammatory lung diseases and identify the mechanism of action (MOA) of breakthrough therapies.
- Drive pipeline research while actively exploring new biologies and pathways for target discovery.
- Facilitate fruitful, open collaborations across immunology, human genetics, biomarker discovery, and early clinical development.
- Present research findings effectively at intra- and inter-departmental scientific meetings.
Who you are
- PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field, with a demonstrated record of high-quality publications.
- Deep understanding of lung biology, particularly in chronic respiratory diseases, tissue remodeling/regeneration, or host-microbe interactions.
- Strong hands-on expertise in molecular biology, including cellular transfections, gene expression profiling, precision genome editing, and targeted RNA delivery technologies.
- Hands-on experience with primary cell isolation from human or mouse tissues, in vitro immunological assays, and multi-dimensional flow cytometry.
- Track record of independently designing, executing, troubleshooting, and interpreting complex experiments leading to first-author publication(s) in top-tier journals.
Preferred
- Proven experience with complex in vitro systems, including airway/alveolar organoids, air-liquid interface (ALI) 3D cultures, or organ-on-a-chip technologies.
- Experience with targeted therapeutic delivery of nucleic acid modalities (e.g., mRNA, siRNA, ASOs) using viral or non-viral vectors.
- Experience with computational data analysis, including scRNA-seq, spatial transcriptomics, or mining public/clinical datasets.
Requirements
- PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field
- Demonstrated record of high-quality publications
- Deep understanding of lung biology, particularly in chronic respiratory diseases, tissue remodeling/regeneration, or host-microbe interactions
- Strong hands-on expertise in molecular biology, including cellular transfections, gene expression profiling, precision genome editing, and targeted RNA delivery technologies
- Hands-on experience with primary cell isolation from human or mouse tissues, in vitro immunological assays, and multi-dimensional flow cytometry
- Track record of independently designing, executing, troubleshooting, and interpreting complex experiments leading to first-author publication(s) in top-tier journals
Benefits
- Discretionary annual bonus
- Medical, Dental & Vision
- 401(k) Matching
Company overview
Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.