Scientist 3
Roche
Summary
We are seeking a motivated and detail-oriented Scientist 3 to join our Formulation team. In this hands-on laboratory role, you will independently execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.
Job description
The Opportunity
- Independently execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) encapsulating nucleic acids for in vitro and in vivo studies.
- Lead DoE-based screening campaigns directed toward discovering LNPs, setting LNP composition specifications, and optimizing LNP formulations.
- Collaborate cross-functionally with internal teams (biology, analytics, chemistry, and project management) to advance programs.
- Support early-stage formulation development and downstream processing activities, including cryoprotection, scale-up, and stability studies as needed.
- Maintain detailed records documenting formulation activities and results.
- Analyze, interpret, and present experimental data in group meetings.
- Troubleshoot formulation challenges and continuously improve workflows.
This is an onsite role based in San Diego, CA. Relocation benefits are not being offered for this position.
Who You Are (Required)
- PhD in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with relevant academic and/or biopharma industry experience; OR a Master's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 3+ years of industry experience.
- 2 or more years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA) for in vitro and in vivo studies.
- Highly proficient with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
- Demonstrated level of expertise in MS Excel; hands-on experience with statistical and data analysis software (e.g., JMP, Prism).
- Demonstrated level of experience in the LNP field in the form of publications and/or patent filings.
Preferred
- Experience with Tangential Flow Filtration (TFF) and bioconjugation chemistry is highly desirable.
- Experience working in an FDA-regulated environment.
- Strong communication skills including the ability to communicate with all levels within the organization; hands-on, self-directed, organized, conscientious.
- Strong problem-solving, judgment and decision-making skills.
- Strong time management and organizational skills in a dynamic, continually changing environment; ability to respond effectively to sensitive inquiries, customer inquiries or complaints as well as communicate effectively both orally and in writing with management, peers and individuals.
- Ability to work effectively, exhibit a professional manner and establish constructive working relationships.
- Excellent written and verbal communication skills.
Requirements
- PhD in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with relevant academic and/or biopharma industry experience; OR a Master's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 3+ years of industry experience.
- 2 or more years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA) for in vitro and in vivo studies.
- Highly proficient with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
- Demonstrated level of expertise in MS Excel; hands-on experience with statistical and data analysis software (e.g., JMP, Prism).
- Demonstrated level of experience in the LNP field in the form of publications and/or patent filings.
Benefits
- Discretionary annual bonus
- Medical, Dental & Vision
- 401(k) Matching
- Paid Time Off
Company overview
Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.