Scientist 3, Single Cell & Functional Genomics
Roche
Summary
The Department of Cell and Tissue Genomics is seeking a creative, rigorous, and motivated Scientist 3 to execute cutting-edge single-cell and functional genomic techniques to study cancer biology. The successful candidate will perform high-throughput screens, deploy new and existing single cell profiling methods, and analyze genomic data to enable the interrogation of molecular mechanisms underlying disease states and identify candidate targets for therapeutic interventions. Working in collaboration with colleagues in the departments of Research Oncology, Translational Medicine, and/or Computational Sciences, this is a hands-on position with both experimental and computational analysis components.
Job description
The Opportunity
- Perform high-throughput screens in cancer cell lines and models
- Develop and apply single cell technologies to profile primary tissue samples.
- Analyze and interpret single cell perturbation data and broader genomic data.
- Effectively collaborate with teams within the department and across the wider organization.
- Communicate results clearly through high-impact scientific publications and presentations.
- Contribute to identifying new research opportunities and innovative technology applications.
Who You Are
- Education: Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering.
- Screening Experience: Hands-on experience performing and analyzing single cell CRISPR screens.
- Data Analysis: Experience in the analysis of single cell and genomic data using R and/or Python.
- NGS Assay Expertise: Strong foundational background in NGS assays and molecular biology techniques.
- Professional Skills: Excellent oral and written presentation skills.
- Leadership: Ability to manage multiple projects in parallel, collaborate effectively with multidisciplinary teams, and lead research projects.
- Scientific Productivity: Sustained record of productivity in the form of publications and patents.
Preferred
- Epigenomics: Experience with epigenomic assays and data analysis.
- Disease Expertise: Experience in cancer biology research.
Requirements
- Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering.
- Hands-on experience performing and analyzing single cell CRISPR screens.
- Experience in the analysis of single cell and genomic data using R and/or Python.
- Strong foundational background in NGS assays and molecular biology techniques.
- Excellent oral and written presentation skills.
- Ability to manage multiple projects in parallel, collaborate effectively with multidisciplinary teams, and lead research projects.
- Sustained record of productivity in the form of publications and patents.
Benefits
- Relocation benefits
- Discretionary annual bonus
- Health insurance
- Equal opportunity employer
Company overview
Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.