Scientist - Analytical Method Development SMDD Foundry Readiness
Eli Lilly and Company
Summary
Synthetic Molecule Design and Development has an exciting opportunity for an analytical chemist to join our development group. In this hands-on laboratory role (>70% bench work), you will develop analytical methods and characterize chemical processes to advance drug candidates from early development through manufacturing readiness. You will expand and apply your expertise in chromatographic method development and leverage complementary techniques (mass spectrometry, NMR) while partnering closely with synthetic chemists and process engineers to solve critical process development challenges. The ideal candidate brings practical chromatography experience, strong problem-solving skills, and the ability to translate analytical data into actionable insights for project teams.
Job description
Position Responsibilities
- Develop and optimize analytical methods to accurately measure purity, potency, and other critical quality attributes of small molecule drug substances and synthetic intermediates.
- Select and implement appropriate analytical techniques (HPLC, GC, NMR, MS) to support chemical process development—independently generating data that elucidates reaction mechanisms, characterizes kinetic behavior, and identifies process-related impurities.
- Collaborate with synthetic chemists and process engineers to ensure analytical methods are suitable for guiding development activities and can be successfully transferred to GMP laboratories for routine testing and manufacturing support.
- Perform laboratory activities with a strong emphasis on safety and technical rigor, while adhering to local policies and procedures.
- Identify and apply new scientific concepts, exhibit strong problem-solving skills, and be self-motivated to contribute across multiple projects.
- Demonstrate strong written and verbal communication skills to represent both the technical aspects and business-related implications of your work.
Basic Qualifications
- Bachelor's degree in Analytical Chemistry, Biochemistry, Chemistry, or a related field with 2+ years of relevant experience
- Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1
Additional Skills/Preferences
- Experience with chromatographic (LC, GC, IC) method development or validation in pharmaceutical, chemical, or regulated industry setting
- Working knowledge of mass spectrometry (LC-MS, GC-MS) and NMR spectroscopy
- Familiarity with chemical process development, synthetic organic chemistry, and rationales for establishing material specifications and testing plans.
- Experience troubleshooting and maintaining analytical instrumentation.
- Demonstration of scientific leadership and the ability to influence others.
- Ability to balance multiple responsibilities, prioritize activities, and navigate ambiguity.
Additional Information
- Potential exposure to chemicals, allergens, and loud noises
- Travel: 0 to 10%
- Position Local: Indianapolis, IN; Lilly Technology Center-North (LTC-N)
Requirements
- Bachelor's degree in Analytical Chemistry, Biochemistry, Chemistry, or a related field
- 2+ years of relevant experience
- Authorized to work in the United States on a full-time basis
- No sponsorship for work authorization or visas
- Experience with chromatographic (LC, GC, IC) method development or validation in pharmaceutical, chemical, or regulated industry setting
- Working knowledge of mass spectrometry (LC-MS, GC-MS) and NMR spectroscopy
- Familiarity with chemical process development, synthetic organic chemistry, and material specifications
- Experience troubleshooting and maintaining analytical instrumentation
- Demonstration of scientific leadership and ability to influence others
- Ability to balance multiple responsibilities, prioritize activities, and navigate ambiguity
Benefits
- 401(k) Matching
- Pension
- Vacation Benefits
- Medical, Dental & Vision
- Prescription Drug Benefits
- Flexible Spending Accounts
- Life Insurance
- Death Benefits
- Employee Assistance Program
- Fitness Benefits
- Company Bonus
Company overview
Eli Lilly and Company, commonly known as Lilly, is a leading American multinational pharmaceutical corporation headquartered in Indianapolis, Indiana. Founded in 1876 by Colonel Eli Lilly, the company has grown into one of the world's most valuable pharmaceutical enterprises, with operations in approximately 125 countries. Lilly specializes in developing and manufacturing innovative medicines across multiple therapeutic areas, including diabetes, oncology, neuroscience, immunology, and cardiometabolic diseases. The company is renowned for its groundbreaking work in insulin production, having been the first to mass-produce insulin and later developing the first commercially available insulin product in the U.S. Lilly's current portfolio includes blockbuster medications such as Mounjaro and Zepbound (tirzepatide) for diabetes and obesity, Trulicity (dulaglutide) for type 2 diabetes, Verzenio (abemaciclib) for breast cancer, and Taltz (ixekizumab) for autoimmune conditions. With approximately 47,000 employees worldwide, Lilly maintains a strong commitment to research and development, investing heavily in scientific innovation to address some of the world's most significant health challenges. The company operates with a mission to make life better for people around the world through the discovery and delivery of innovative medicines.