Scientist, Biology
Alector
Summary
As a Scientist on our Biology team, you will design and execute in vitro studies and analytical assays that help us evaluate potential therapeutics for neurodegenerative diseases. You will work with advanced cellular models, process in vivo and in vitro samples, and generate high-quality data that inform pharmacokinetics/pharmacodynamics (PK/PD), efficacy, safety, proof-of-concept (POC), and mechanism-of-action (MOA) studies. You'll collaborate closely with colleagues across Biology, ADPE, and Preclinical teams to advance our programs.
Job description
Key Goals and Accountabilities
- Design and execute in vitro pharmacology studies using iPSC-derived cellular models, including induced neurons, induced microglia, and co-culture and triple-culture systems.
- Develop and optimize cellular models of neurodegenerative disease, including Alzheimer's disease, to enable POC and MOA studies.
- Collect and process cell lysates, media, rodent brain, and other biological samples and perform downstream biochemical and cellular analyses.
- Analyze, interpret, document, and communicate results while maintaining accurate experimental records, protocols, and data in our electronic lab notebook.
- Collaborate across Biology, ADPE, and Preclinical teams while identifying opportunities to integrate innovative technologies, especially AI, to expedite programs, improve scientific workflows, and save valuable resources.
Required Qualifications
- PhD in Neuroscience, Immunology, Biology, or a related scientific discipline.
- Hands-on experience with cell culture, including iPSC-derived and/or primary rodent neuronal models.
- Experience with biochemical and cellular techniques such as immunoblotting, ELISA, MSD, immunocytochemistry, flow cytometry/FACS, or immunohistochemistry.
- Demonstrated ability to analyze and interpret experimental data and clearly communicate scientific findings.
- You are an active user of large language models (LLMs) and have a strong interest in evolving AI technologies and how they can improve scientific research and productivity.
Preferred Qualifications
- Experience working in a biotechnology or pharmaceutical research environment.
- Experience developing or optimizing cellular models of neurodegenerative disease.
- Familiarity with confocal microscopy and neurohistology techniques.
Requirements
- PhD in Neuroscience, Immunology, Biology, or a related scientific discipline
- Hands-on experience with cell culture, including iPSC-derived and/or primary rodent neuronal models
- Experience with biochemical and cellular techniques such as immunoblotting, ELISA, MSD, immunocytochemistry, flow cytometry/FACS, or immunohistochemistry
- Demonstrated ability to analyze and interpret experimental data and clearly communicate scientific findings
- Active user of large language models (LLMs) with strong interest in evolving AI technologies
- Experience working in a biotechnology or pharmaceutical research environment
- Experience developing or optimizing cellular models of neurodegenerative disease
- Familiarity with confocal microscopy and neurohistology techniques
Benefits
- Flexible hybrid work options
- Competitive compensation
- Comprehensive health benefits
- Well-being programs
Company overview
Alector is a clinical-stage biotechnology company focused on developing innovative immunotherapies for neurodegenerative diseases and cancer. Founded in 2013 and headquartered in South San Francisco, California, the company leverages advanced antibody technology and insights from neuroimmunology to create potential first- and best-in-class medicines. Alector's pipeline includes therapeutic candidates targeting Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions through its proprietary Alector Brain Carrier (ABC) technology designed to transport therapies across the blood-brain barrier. The company combines expertise in human genetics, neuroscience, and immunology to develop treatments that aim to remove toxic proteins, replace deficient proteins, and restore immune and nerve cell function. With approximately 240 employees, Alector operates as a publicly traded company (NASDAQ: ALEC) and has established collaborations with major pharmaceutical partners while maintaining a strong focus on creating transformative therapies for devastating brain disorders.