Scientist, Cardiac Vascular - In Vivo
Regeneron Pharmaceuticals
Summary
We are seeking a Cardiac and Vascular Rodent Surgeon to join our cardiovascular research team, serving as a key contributor to the design and execution of longitudinal in-vivo rodent studies supporting our cardiovascular disease programs. In this role, you will perform advanced surgical models of cardiac disease, conduct precision dosing and physiological monitoring, and generate high-quality functional and molecular data to support target validation and therapeutic development.
Job description
Discover your role
- Perform surgical models of cardiac and vascular disease in mice and rats, including transverse aortic constriction (TAC), myocardial infarction (MI), and renal/kidney models (RKM)
- Administer test articles via multiple routes (IV, SC, IM) or osmotic minipump implantation with precision and consistency across longitudinal study timelines
- Implant and manage telemetry devices for continuous blood pressure and ECG monitoring in conscious, freely moving rodents
- Conduct invasive hemodynamic assessments using PV-loop methodology to quantify cardiac function
- Perform ex-vivo tissue collection and processing, including cardiac dissociation via Langendorff perfusion
- Manage end-to-end in-vivo study logistics, including animal health monitoring, surgical scheduling, and post-operative care
- Analyze and interpret physiological, hemodynamic, and functional data using PRISM, PONEMAH, and other relevant analysis software
- Generate high-quality figures, reports, and data summaries for internal presentations, regulatory packages, and peer-reviewed publications
- Maintain rigorous records of surgical procedures, animal welfare documentation, and study protocols in compliance with institutional and regulatory standards
- Collaborate closely with study directors, therapeutic area scientists, and cross-functional teams to align surgical and analytical approaches with program goals
- Proactively flag capacity constraints, scheduling conflicts, or technical challenges to stakeholders
This role requires
- BS with 10+ years, MS with 6+ years with relevant experience in a related field (e.g., Physiology, Biomedical Sciences, Veterinary Science, or similar)
- Demonstrated hands-on expertise in rodent cardiac and vascular surgical models (TAC, MI, RKM)
- Proficiency in rodent dosing techniques (IV, SC, IM) and telemetry implantation for blood pressure and ECG monitoring
- Experience with invasive hemodynamic measurement techniques, including PV-loop analysis
- Hands-on experience with Langendorff perfusion and cardiac tissue dissociation
- Proficiency with data analysis software such as PRISM and PONEMAH
- Strong understanding of rodent anatomy, physiology, and survival surgery best practices
- Excellent organizational skills, with the ability to manage multiple longitudinal studies and competing priorities simultaneously
- Strong attention to detail and commitment to scientific rigor and animal welfare standards
- Excellent oral and written communication skills
- Preferred: experience with additional cardiovascular functional assessment techniques or prior work in a GLP/regulated research environment
Requirements
- BS with 10+ years or MS with 6+ years of relevant experience in a related field (e.g., Physiology, Biomedical Sciences, Veterinary Science, or similar)
- Demonstrated hands-on expertise in rodent cardiac and vascular surgical models (TAC, MI, RKM)
- Proficiency in rodent dosing techniques (IV, SC, IM) and telemetry implantation for blood pressure and ECG monitoring
- Experience with invasive hemodynamic measurement techniques, including PV-loop analysis
- Hands-on experience with Langendorff perfusion and cardiac tissue dissociation
- Proficiency with data analysis software such as PRISM and PONEMAH
- Strong understanding of rodent anatomy, physiology, and survival surgery best practices
- Excellent organizational skills, with the ability to manage multiple longitudinal studies and competing priorities simultaneously
- Strong attention to detail and commitment to scientific rigor and animal welfare standards
- Excellent oral and written communication skills
- Preferred: experience with additional cardiovascular functional assessment techniques or prior work in a GLP/regulated research environment
Benefits
- Annual bonuses
- Incentive plans
- Equity awards
- Pension or retirement benefits
- 401(k) company match
- Health and wellness programs
- Fitness centers
- Insurance benefits
- Paid time off
- Family support benefits
Company overview
Regeneron Pharmaceuticals is a leading American biotechnology company founded in 1988 and headquartered in Tarrytown, New York. The company specializes in inventing, developing, and commercializing life-transforming medicines for people with serious diseases. Regeneron is renowned for its innovative antibody technologies and has developed several groundbreaking therapies, including EYLEA® for retinal diseases, DUPIXENT® for inflammatory conditions, and the COVID-19 antibody cocktail REGEN-COV®. The company operates with a strong focus on research and development across multiple therapeutic areas including ophthalmology, oncology, cardiovascular diseases, and rare genetic disorders. Regeneron's proprietary VelocImmune® technology platform enables the rapid generation of fully human monoclonal antibodies. With over 15,000 employees globally and annual revenues exceeding $14 billion, Regeneron has established itself as a major force in the biotechnology industry, consistently ranking among the top-performing pharmaceutical companies and maintaining a robust pipeline of investigational therapies.