Scientist, Cell Therapy Bioscience

Position Summary

This is a predominantly laboratory-based discovery position focused on the in vitro generation, characterization and functional evaluation of engineered immune-cell therapies. The successful candidate will provide hands-on experimental support to CAR-T projects while contributing to Cell Therapy platform capabilities that can be applied across programs.

In this role, you will combine T- and NK-cell biology, cellular engineering, functional assay development and multiparameter flow cytometry to address key biological and translational questions. You will design and execute experiments with increasing independence, analyze and interpret experimental data, and translate findings into clear conclusions and next steps.

Key Responsibilities

• Conduct, troubleshoot, analyze independently in vitro Cell Therapy and immunology experiments.
• Culture and characterize primary T and NK cells, including phenotyping and functional assays.
• Engineer T cells using viral and/or non-viral approaches.
• Contribute to Cell Therapy platform development by establishing, optimizing and applying reusable assays, workflows, controls and data-analysis approaches across programs.
• Design and execute immune-cell functional assays, including activation, cytotoxicity, proliferation, cytokine production, serial or repeated challenge, phenotype, fitness, persistence and other relevant readouts.
• Plan and perform multiparameter flow cytometry experiments, including panel design, staining, acquisition, quality control, analysis and biological interpretation.
• Apply cellular and molecular methods relevant to CAR-T discovery, including primary-cell isolation and culture, transfection or electroporation, viral transduction, gene-editing support and molecular characterization.
• Support in vitro assessment of allogeneic rejection biology, including host-versus-graft and graft-versus-host responses, using immune-cell co-culture, mixed lymphocyte reaction or related assays.
• Use appropriate statistical, visualization and reproducible data-handling practices to analyze experimental results and define clear conclusions and next experiments.
• Use approved digital and AI-enabled tools, where appropriate, to support data analysis, visualization, literature synthesis, documentation and experimental planning, with appropriate scientific review and protection of confidential information.
• Integrate findings across functional assays, flow cytometry and, where relevant, omics or in vivo datasets in collaboration with computational, bioinformatics and in vivo partners.
• Maintain accurate experimental records and communicate results, interpretations, limitations and recommendations clearly through reports, presentations and project discussions.
• Collaborate effectively within multidisciplinary project teams and ensure work is conducted in accordance with applicable laboratory, data-integrity, biosafety, Safety, Health & Environment, quality and regulatory requirements.

Essential Requirements

• BS or MS in Immunology, Cell Biology, Molecular Biology, Bioengineering or a related scientific discipline, with approximately 3 or more years of relevant research experience.
• Hands-on experience with primary human immune-cell culture and established tumor cell lines.
• Practical experience in T-cell and/or NK-cell biology, Cell Therapy, Immunology, Immuno-Oncology or a closely related field.
• Experience performing immune-cell functional assays, such as cytotoxicity, proliferation, activation and cytokine measurements.
• Experience with flow cytometry acquisition and analysis, with the ability to interpret data in the context of the biological question.
• Ability to contribute to experimental design, troubleshoot laboratory studies, interpret results critically and identify appropriate next steps.
• Strong organization, documentation and communication skills, with the ability to manage several laboratory activities and deliver reliable data within project timelines.
• Ability to work collaboratively in multidisciplinary project teams while maintaining accountability for assigned experimental work.
• Comfort using standard data-analysis and visualization software and willingness to adopt approved AI-enabled tools to improve daily scientific analysis and productivity.

Desired Qualifications

• Experience generating or characterizing CAR-T, TCR-T, engineered NK cells or other genetically modified immune-cell therapies.
• Familiarity with viral transduction, electroporation, CRISPR/Cas or other gene-editing and cellular-engineering approaches.
• Knowledge of allogeneic Cell Therapy and mechanisms of immune rejection, including host-versus-graft and graft-versus-host biology.
• Hands-on experience developing or running in vitro allorejection assays, including mixed lymphocyte reactions, immune-cell co-cultures or related functional assays.
• Experience using established bioinformatics, automation or AI-assisted tools for biological data interpretation, literature review, documentation or experimental planning.
• Previous experience in a pharmaceutical or biotechnology research environment is preferred.