Scientist - Endometrial Biology
e184
Summary
As a Scientist at e184, you will lead research aimed at understanding the molecular and cellular mechanisms that govern implantation and peri-implantation development. Your work will focus on developing and applying advanced endometrial model systems to identify the signaling, structural, and physiological interactions that enable successful embryo-maternal communication. Working closely with developmental biologists, engineers, and computational scientists, you will design experiments that translate fundamental reproductive biology into experimentally testable systems that inform platform development for ex utero gestation. This is a highly hands-on role for a scientist with deep expertise in endometrial biology who is excited to apply mechanistic insight toward building next-generation reproductive technologies in a fast-paced, collaborative startup environment.
Job description
What you'll do
- Develop endometrial model systems: Establish, optimize, and maintain in vitro endometrial models, including primary cells, organoids, or engineered tissue systems that recapitulate peri-implantation physiology.
- Investigate implantation mechanisms: Design and execute experiments to identify molecular pathways regulating embryo attachment, invasion, decidualization, and early maternal-fetal signaling.
- Characterize cellular and molecular responses: Apply imaging, histology, transcriptomics, and molecular assays to evaluate endometrial receptivity, cellular differentiation, and tissue remodeling.
- Define embryo–endometrium interactions: Develop assays to study signaling and structural interactions during implantation and early development, integrating biological findings into experimental platform design.
- Integrate multi-modal datasets: Analyze and interpret molecular, imaging, and functional data to generate mechanistic insight and guide experimental iteration.
- Collaborate across disciplines: Partner with embryology, bioengineering, and computational teams to translate biological findings into design requirements for experimental systems supporting early development.
Core requirements
- PhD in Reproductive Biology, Developmental Biology, Cell Biology, Molecular Biology, or a related field, or 5+ years of relevant academic or industry experience
- Demonstrated expertise in endometrial biology, implantation biology, or maternal–fetal interface research
- Hands-on experience with mammalian cell culture and endometrial model systems (primary cells, stromal/epithelial co-culture, or organoids)
- Strong understanding of decidualization, endometrial receptivity, and peri-implantation developmental processes
- Experience designing and executing mechanistic biological experiments independently
- Excellent organizational skills and attention to experimental rigor
- Ability to work collaboratively in an interdisciplinary research environment
- Enthusiasm for mission-driven science within a fast-paced startup setting
You'll stand out with
- Experience working with human endometrial organoids or advanced in vitro implantation models
- Expertise in hormone-responsive endometrial systems and decidualization assays
- Hands-on histology experience, including tissue processing, sectioning, staining, and microscopy-based analysis
- Experience with transcriptomics, single-cell sequencing, or spatial omics approaches
- Background studying embryo–maternal signaling pathways or early placentation
- Experience integrating molecular datasets with functional developmental outcomes
- Prior startup, translational research, or early-stage technology development experience
Requirements
- PhD in Reproductive Biology, Developmental Biology, Cell Biology, Molecular Biology, or a related field, or 5+ years of relevant academic or industry experience
- Demonstrated expertise in endometrial biology, implantation biology, or maternal–fetal interface research
- Hands-on experience with mammalian cell culture and endometrial model systems (primary cells, stromal/epithelial co-culture, or organoids)
- Strong understanding of decidualization, endometrial receptivity, and peri-implantation developmental processes
- Experience designing and executing mechanistic biological experiments independently
- Excellent organizational skills and attention to experimental rigor
- Ability to work collaboratively in an interdisciplinary research environment
- Enthusiasm for mission-driven science within a fast-paced startup setting
Benefits
- Competitive salary
- Equity participation
- Medical insurance
- Dental insurance
- Vision insurance
- 401(k) with company match
- 20 days PTO
- 11 paid holidays
Company overview
e184 is a pioneering biotechnology company founded in 2023 that operates at the intersection of reproductive medicine and neurotechnology. The company is developing groundbreaking technologies in two main areas: advanced reproductive solutions and next-generation brain-computer interfaces. In reproductive biotechnology, e184 is working on in vitro gametogenesis (IVG) to create gametes from tissue samples and developing artificial womb technologies, aiming to provide reproductive freedom and address infertility challenges for millions worldwide. Simultaneously, the company is building non-invasive brain-computer interfaces with unprecedented resolution to enable seamless human-AI collaboration. With laboratories in Portland, Oregon and headquarters in Grand Cayman, e184 collaborates with leading scientific advisors from institutions like Howard Hughes Medical Institute and Kumamoto University. The company's mission focuses on enabling reproductive rights for all while advancing neurotechnology for the next stage of human development, positioning itself at the forefront of biotechnology innovation.