Scientist, High Throughput Antibody Production

Role Summary

We are seeking a highly organized, detail-oriented Scientist to join our High-Throughput Production (HTP) team in Cambridge, MA. The successful candidate will use an advanced, integrated robotics laboratory to routinely produce, purify, and quality-control hundreds of antibodies and antibody-like therapeutic molecules each week in support of R&D pipeline programs. Working within validated, end-to-end automated workflows designed to enable near-lights-out production, this role is accountable for reliable execution, complete documentation, instrument and material readiness, and timely delivery of high-quality samples and data.

Main Duties & Responsibilities

• Execute scheduled, high-throughput transient expression, purification, and sample-preparation campaigns for antibodies, multispecifics, and recombinant fragments, routinely supporting delivery of hundreds of molecules per week across R&D pipeline programs.
• Operate liquid handlers and integrated robotics platforms, including Hamilton and Lynx systems and Cellario orchestration software, using approved methods; complete deck setup, barcode and consumable checks, run monitoring, recovery steps, and basic troubleshooting in accordance with SOPs.
• Prepare media, reagents, plates, and consumables; culture CHO and HEK293 cells; perform aseptic transient transfections; harvest via filtration or centrifugation in accordance with SOPs.
• Perform routine production and QC testing according to established methods, including concentration, purity, identity, and other fit-for-purpose biochemical, biophysical, or functional measurements; assess results against acceptance criteria and compile complete, traceable data packages for project teams.
• Track samples, inventory, and metadata in laboratory logistics/LIMS software to maintain chain-of-custody and ensure timely delivery and data completeness.
• Maintain automation and analytical instrumentation readiness through preventive maintenance, calibrations, and upkeep of equipment logs; coordinate vendor service when required.
• Coordinate daily work with HTP colleagues and cross-functional partners to meet weekly throughput, quality, and turnaround targets; communicate status, dependencies, deviations, and delivery risks clearly and promptly.
• Follow detailed SOPs, work instructions, and production schedules precisely; recognize and escalate departures from expected performance, and contribute practical observations that strengthen process robustness and operational consistency.
• Engage with AI/ML and automation tools as they are introduced into workflows, and actively contribute ideas for improving data interpretation, hit triage, and overall efficiency in the drug discovery pipeline.

Education & Experience Requirements

• Master’s degree in biochemistry, biotechnology, cell biology, molecular biology, chemical engineering, or a related discipline, with 1+ years of relevant experience in high-throughput protein or antibody expression, purification, or analytical characterization.
• Bachelor’s degree in a related scientific or engineering discipline, with 5+ years of relevant experience in high-throughput protein or antibody expression, purification, or analytical characterization.

Required Skills

• Demonstrated hands-on experience with high-throughput production of antibodies or recombinant proteins, including routine execution of standardized workflows at microgram-to-milligram scale.
• Hands-on experience operating automated liquid handlers; experience with Hamilton or Lynx platforms is preferred, and familiarity with integrated robotics or scheduling/orchestration software such as Cellario is strongly valued.
• Fundamental understanding of recombinant protein expression and purification, including mammalian cell culture, aseptic technique, transient transfection, affinity capture, buffer exchange, concentration, and factors that affect yield and product quality.
• Experience with sample tracking and laboratory logistics/LIMS software; comfort with barcode-driven workflows.
• Strong organizational skills and the ability to prepare production runs, manage multiple samples and consumables, maintain accurate records, and consistently meet time-sensitive weekly deliverables.
• Exceptional attention to detail, documentation rigor, and demonstrated ability to follow detailed SOPs, work instructions, process controls, and QC acceptance criteria without compromising quality or traceability.
• Team-oriented, dependable, and collaborative, with clear written and verbal communication skills and a willingness to coordinate closely, share workload, and support colleagues across production, QC, automation, and pipeline-facing teams.

Desired Skills

• Working knowledge of protein purification technologies and common analytical methods (e.g., SEC-UPLC, LC-MS, SDS-PAGE, CE).
• Familiarity with lab automation scheduling software; Cellario preferred.
• Basic scripting for data handling (e.g., Python, Jupyter) is a plus, not required.