Scientist I

Here's what you'll do:

• Be responsible for screening cell-based assays in an operations setting using plate reader such as EnVision or FLIPR instrumentation, liquid handling, and other lab automation.
• Serve as the primary point of contact and lead for assigned assay sets, responsible for developing the weekly assay schedule and independently executing assays with minimal supervision.
• Co-ordinate multiple projects simultaneously. This includes efforts for a bi-weekly large-scale safety pharmacology panel, routinely scheduled screens, HTS campaigns, and ad-hoc requests.
• Maintain all (25+) cell lines needed for the operation and providing screening plates or assays ready cells according to the business needs.
• Maintain inventory of bulk vials to sustain the business continuity.
• Support compound management by utilizing acoustic dispensing (Echo or ATS).
• Be in charge of optimizing screening assays to improve TAT.
• Coordinate cross-site screening facility efforts.
• Set up training for new employees, establish and curate SOPs and routine QC.
• Be heavily involved in data management while optimizing workflow and remedy error prone steps and understand data management in CBIS.
• Independently analyze screening results, provide initial data QC using Spotfire or other data visualization tools. Perform large-scale data analysis and generate customer reports.
• Maintain accurate and organized records for all assay related work.

Qualifications

The ideal candidate:

• B.S. in biological sciences with 2-5 years of relevant experience.
• Experience working in an operations type screening lab maintaining mammalian cell lines is required.
• Experience performing and analyzing quantitative cell-based and/or biochemical assays is required.
• Experience with data management, including databases; assay troubleshooting experience.
• Maintains accurate and organized records for assay.
• Skilled in mammalian cell culture, biochemical and/or cell-based assay design, execution, and analysis.
• Skilled with data management and analysis software (i.e. Excel/GraphPad Prism or similar).
• Outstanding oral and written communication skills.
• Excellent scheduling skills.
• Skilled in assay troubleshooting and data management.
• Ability to work in the U.S. indefinitely without sponsorship.

The position is full-time, Monday-Friday, 8 a.m.- 5 p.m., with overtime as needed. Candidates within a commutable distance of San Diego, CA are encouraged to apply.