Scientist I, Large Molecule Bioanalysis LC-MS
Neurocrine Biosciences
Summary
We are seeking a Scientist in Large Molecule Bioanalysis to support preclinical development of peptides, antibodies, proteins, ADCs, and other protein conjugates. The role will primarily involve hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis and biotransformation assessment.
Job description
About The Role
We are seeking a Scientist in Large Molecule Bioanalysis to support preclinical development of peptides, antibodies, proteins, ADCs, and other protein conjugates. The role will primarily involve hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis and biotransformation assessment.
Your Contributions (include, But Are Not Limited To)
- Develop and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices
- Develop, optimize, and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices
- Support bioanalysis of samples from preclinical PK/TK and other nonclinical studies
- Perform immunoprecipitation/immunoaffinity enrichment, protein digestion, and surrogate peptide quantitation
- Perform intact protein analysis, peptide mapping, and bottom-up LC-HRMS analysis
- Support biotransformation assessment of ADCs and protein conjugates using hybrid LC-HRMS
- Analyze, document, and communicate experimental results and contribute to method improvements
Requirements
- BS in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field with 2+ years of relevant experience in bioanalysis or MS with some industry experience preferred
- Hands-on experience with LC-MS analysis of proteins or peptides in plasma, serum, tissue, or other biological matrices
- Experience with hybrid LC-MS, immunoaffinity workflows, protein digestion, and high-resolution MS
- Experience with peptide/protein quantitation and bioanalytical method development
- Experience supporting preclinical bioanalysis and/or GLP method transfer is preferred
- Familiarity with Skyline, Analyst, TraceFinder, Chromeleon, or BioPharma Finder is beneficial
Benefits
- 401(k) Matching
- Paid Vacation
- Holiday & Personal Days
- Paid Caregiver/Parental Leave
- Medical, Dental & Vision
- Annual Bonus
- Equity Long Term Incentive
Company overview
Neurocrine Biosciences is a leading neuroscience-focused biopharmaceutical company founded in 1992 and headquartered in San Diego, California. The company specializes in discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. Neurocrine's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis, and uterine fibroids. Their flagship product, INGREZZA (valbenazine), was the first FDA-approved treatment for adults with tardive dyskinesia. The company maintains a robust pipeline with multiple compounds in mid- to late-phase clinical development across core therapeutic areas, including Parkinson's disease, Tourette syndrome, and major depressive disorder. Neurocrine operates with a purpose to relieve suffering for people with great needs, applying unique insights into neuroscience and the interconnections between brain and body systems to treat complex conditions. The company is publicly traded on NASDAQ under the symbol NBIX and has established strategic collaborations with major pharmaceutical partners including AbbVie.