Scientist I, Medicinal Chemistry
Revolution Medicines
Summary
Revolution Medicines is seeking a scientifically talented individual to join our world-class Discovery Research organization as a Scientist I, Medicinal Chemistry. This individual contributor role will work as a key member of an integrated, multidisciplinary drug discovery team making significant contributions toward the discovery of important new drug candidates.
Job description
Responsibilities
- Design and synthesis of biologically active compounds to support SAR: analysis of biological data, SBDD based design of analogs, planning and execution of the synthetic routes, synthesis purification of final targets.
- Recommend alternative synthetic routes, research new methods and techniques, and proactively seek out others to identify solutions to challenges.
- Present research findings to the Medicinal Chemistry team and management.
- Partner in the scientific activities of other outstanding medical chemists and cross functional team members and create an environment where all ideas are shared.
- Collaboration with external teams, CROs (contract research organizations).
Required Skills, Experience and Education
- Ph.D. with a background in synthetic organic chemistry and 0-3 years of postdoctoral or relevant pharma/biotech industry experience.
- Strong understanding of synthetic organic and medicinal chemistry.
- Experience with NMR, HPLC, and Mass Spectrometry techniques.
- Familiar with modern synthetic, organic chemistry techniques and instrumentation.
- Well versed in synthetic methodologies and can independently design and execute synthetic procedures.
- Strong written and verbal communication skills to work with interdepartmental teams.
- Ability to multi-task, be efficient and well-organized, and work collaboratively as a team player with high energy in a dynamic and fast-paced environment.
Preferred Skills
- Demonstrated experience in the total synthesis of complex molecules, including multistep route design, synthetic problem-solving, and stereochemical control.
- Experience in beyond Rule-of-Five (bRo5) small-molecule drug discovery.
- Experience in oncology drug discovery research.
Requirements
- Ph.D. with a background in synthetic organic chemistry
- 0-3 years of postdoctoral or relevant pharma/biotech industry experience
- Strong understanding of synthetic organic and medicinal chemistry
- Experience with NMR, HPLC, and Mass Spectrometry techniques
- Familiar with modern synthetic, organic chemistry techniques and instrumentation
- Well versed in synthetic methodologies and can independently design and execute synthetic procedures
- Strong written and verbal communication skills to work with interdepartmental teams
- Ability to multi-task, be efficient and well-organized, and work collaboratively as a team player with high energy in a dynamic and fast-paced environment
Benefits
- Competitive cash compensation
- Equity awards
- Learning and development opportunities
Company overview
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The company is pioneering a new class of therapeutics that target oncogenic RAS mutations, which are among the most common drivers of human cancers. Revolution Medicines employs a unique approach to drug discovery, leveraging deep insights into RAS biology to develop small molecule inhibitors that can address previously undruggable targets. Their pipeline includes multiple clinical-stage candidates designed to inhibit various RAS pathway mutations, with a particular focus on KRAS G12C and other RAS variants. The company's scientific platform combines structural biology, medicinal chemistry, and computational approaches to design highly selective inhibitors. Revolution Medicines aims to transform cancer treatment by developing therapies that can overcome resistance mechanisms and provide durable clinical benefits for patients with RAS-driven malignancies. Their research represents a significant advancement in the field of targeted cancer therapy, addressing one of the most challenging areas in oncology drug development.