Scientist, In Vivo Pharmacology, Neuroscience
Bristol Myers Squibb
Summary
The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept.
Job description
In the role as a Scientist within In Vivo Pharmacology, the ideal candidate:
- Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing
- Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology.
- Manages in vivo studies conducted at contract research organizations (CROs)
- Serves as an in vivo pharmacology representative on program and platform teams
Basic Qualifications:
- Bachelor’s Degree 5+ years of academic and / or industry experience
- Or Master’s Degree 3+ years of academic and / or industry experience
- Or Ph.D. or equivalent advanced degree in the Life Sciences No experience necessary
Preferred Qualifications:
- PhD in Neuroscience or related field is required.
- Expertise and practical experience in one or more of the following: Neurodegenerative disease, such as Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease, particularly with respect to animal modeling
- Neuromuscular disease, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophies, particularly with respect to animal modeling
- RNA biology and splice modulation
- Genetic medicines, particularly the delivery of siRNAs and/or ASOs across the blood-brain barrier (BBB)
- Extensive mouse handling experience, including common dosing routes and tissue collection from central nervous system (CNS) and peripheral tissues required
- Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays required
- Experience with rodent stereotaxic surgery
- Familiarity with in vivo bioluminescence imaging
- Familiarity with transcriptomics and/or proteomics
- Experience working with contract research organization (CROs)
- Strong organizational and communication skills
- Ability to work independently and as part of a team
- Detail-oriented with a commitment to scientific rigor and reproducibility
- Adaptability in a fast-paced, collaborative research environment
Requirements
- Bachelor’s Degree with 5+ years of academic and/or industry experience, or Master’s Degree with 3+ years, or Ph.D. in Life Sciences
- PhD in Neuroscience or related field is required
- Expertise in animal modeling for neurodegenerative or neuromuscular diseases
- Extensive mouse handling experience, including common dosing routes and tissue collection from CNS and peripheral tissues
- Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays
- Experience with rodent stereotaxic surgery
- Familiarity with in vivo bioluminescence imaging
- Familiarity with transcriptomics and/or proteomics
- Experience working with contract research organizations (CROs)
- Strong organizational and communication skills
- Ability to work independently and as part of a team
- Detail-oriented with a commitment to scientific rigor and reproducibility
- Adaptability in a fast-paced, collaborative research environment
Benefits
- Wellbeing support
- Retirement benefits
- Financial protection benefits
- Medical insurance
- Dental insurance
- Vision insurance
- Life insurance
- Disability insurance
- Flexible Time Off
- Paid company holidays
- Paid sick leave
- Volunteer days
- Summer hours flexibility
- Leaves of absence
- Global shutdown
Company overview
Bristol Myers Squibb is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. Founded in 1887 and headquartered in Princeton, New Jersey, the company operates with a unique BioPharma strategy that combines the reach and resources of a major pharmaceutical company with the entrepreneurial spirit and agility of a biotech firm. BMS focuses on transformative therapies in key therapeutic areas including oncology, hematology, immunology, cardiovascular disease, and fibrosis. The company has built a sustainable pipeline of potential therapies and leverages translational medicine and data analytics to deliver the right medicine to the right patient at the right time. With over 10,000 employees worldwide, Bristol Myers Squibb maintains a strong commitment to scientific excellence, patient-centric innovation, and global health equity through its foundation. The company's portfolio includes groundbreaking treatments such as Opdivo (nivolumab) for cancer, Eliquis (apixaban) for cardiovascular conditions, and Orencia (abatacept) for autoimmune diseases, among others.