Scientist, Large Molecule Analytical (On-site)
Merck
Summary
The Large Molecule Analytical department of our Research & Development Division is seeking applicants for a Scientist position. The Scientist is a laboratory-based scientific role tasked with solving complex analytical problems at the interface of biology, chemistry, and lab informatics disciplines to enable development of Biologics drug substances and drug products.
Job description
Role Description
The Large Molecule Analytical department of our Research & Development Division is seeking applicants for a Scientist position. The Scientist is a laboratory-based scientific role tasked with solving complex analytical problems at the interface of biology, chemistry, and lab informatics disciplines to enable development of Biologics drug substances and drug products.
The successful candidate must function well and be able to collaborate in a fast-paced, integrated, multidisciplinary team environment. The qualified candidate will be responsible for development, qualification, implementation, troubleshooting and transfer of analytical methods for monoclonal proteins or other complex therapeutic proteins.
Applicants must have effective organizational, multi-tasking, oral/written communications skills, show scientific leadership, and a desire to conduct research and publish. Evidence of strong cross-functional collaboration in an academic or industrial setting is also preferred.
Qualifications
BA/BS in analytical chemistry/biochemistry or related field with a minimum of 3 years of experience in the Pharmaceutical Industry, or M.S. with a minimum of 0+ year relevant experience (with expected graduation no later than January 2027).
Required Experience And Skills
- Prior experience in a laboratory environment
- Ability to develop and apply basic principles and scientific concepts to execute work in a laboratory setting
- Execute routine experiments and data interpretation with appropriate technical guidance
- Ability to operate and troubleshoot analytical methods
- Understanding of the fundamentals in separations science
- Experience with UPLC/HPLC analysis of biologics (e.g., SEC, RP, IEX) and CE techniques or molecular biology (PCR, DNA extraction) and immunoassay (ELISA, gel electrophoresis) techniques
- Ability to work within overall project timelines to manage prioritization and execution of individual deliverables with appropriate supervision
- Demonstrated experience working within collaborative team environments
- Experience in authoring and reviewing internal technical reports, sections of regulatory filings (e.g., IND, BLA) and external scientific publications
Preferred Experience And Skills
- Past experience working as part of a project team
- Strong knowledge of protein structure and degradation pathways
- Experience in analysis of various Biologic modalities (e.g., mAb, antibody-drug conjugate, fusion protein)
- Background in Analytical Methodologies and sound scientific understanding of Critical Quality Attributes/QbD/DOE principles
- Prior experience with Microsoft Office and other research applications (e.g., RLIMS, ELN, Empower)
- Experience in data analytics, programming, or laboratory automation
Requirements
- BA/BS in analytical chemistry/biochemistry or related field with a minimum of 3 years of experience in the Pharmaceutical Industry, or M.S. with a minimum of 0+ year relevant experience
- Prior experience in a laboratory environment
- Ability to develop and apply basic principles and scientific concepts to execute work in a laboratory setting
- Execute routine experiments and data interpretation with appropriate technical guidance
- Ability to operate and troubleshoot analytical methods
- Understanding of the fundamentals in separations science
- Experience with UPLC/HPLC analysis of biologics (e.g., SEC, RP, IEX) and CE techniques or molecular biology (PCR, DNA extraction) and immunoassay (ELISA, gel electrophoresis) techniques
- Ability to work within overall project timelines to manage prioritization and execution of individual deliverables with appropriate supervision
- Demonstrated experience working within collaborative team environments
- Experience in authoring and reviewing internal technical reports, sections of regulatory filings (e.g., IND, BLA) and external scientific publications
Benefits
- Medical, Dental & Vision
- Other Insurance Benefits
- 401(k) Retirement Benefits
- Paid Holidays
- Vacation
- Compassionate & Sick Days
- Annual Bonus
- Long-Term Incentive
Company overview
Merck & Co., Inc., known as Merck in the United States and Canada and MSD (Merck Sharp & Dohme) internationally, is a premier American multinational pharmaceutical company headquartered in Rahway, New Jersey. Founded in 1891 as the U.S. subsidiary of the German Merck Group, the company became independent following World War I and has since grown into one of the world's largest biomedical companies, ranking fourth globally by revenue. Merck operates across three core business segments: pharmaceuticals, vaccines, and animal health products. The company is renowned for its groundbreaking research and development, having brought numerous life-saving medicines to market including Keytruda (pembrolizumab), a leading immunotherapy for cancer treatment that generated $29.5 billion in 2024 revenue, and Gardasil, a revolutionary HPV vaccine. With approximately 75,000 employees worldwide, Merck maintains a robust pipeline of innovative therapies focused on oncology, vaccines, hospital acute care, cardiology, neuroscience, virology, immunology, and diabetes. The company invests heavily in R&D, spending $17.9 billion in 2024 alone, demonstrating its commitment to advancing scientific discovery. Merck's legacy spans over 130 years of bringing hope to humanity through important medicines and vaccines, operating with a purpose to use leading-edge science to save and improve lives globally while fostering an inclusive workforce and responsible business practices.