Scientist - LC-MS Bioanalytical
Amgen
Summary
This lab-based role supports the design, development, validation, and implementation of robust LC–MS/MS bioanalytical methods for therapeutic modalities including small molecules, oligonucleotides, proteins, and other complex molecular entities. The initial focus is to expand discovery-stage support within PKDM–BA, while maintaining flexibility to support GLP preclinical and regulated clinical activities as needed. The role will also contribute to modernization of automation and instrumentation to improve assay throughput and sensitivity, working closely with multidisciplinary research and development teams across Amgen.
Job description
Key Responsibilities
- Plan, execute, and document quantitative LC–MS/MS bioanalytical experiments.
- Develop and implement fit-for-purpose bioanalytical methods with rapid turnaround.
- Perform small- and large-molecule bioanalysis in nonclinical and clinical matrices, including plasma, urine, CSF, and tissues.
- Prepare biological samples using protein precipitation, solid-phase extraction, liquid–liquid extraction, affinity capture, and related techniques.
- Organize, analyze, interpret, and present bioanalytical data with strong attention to data integrity and fidelity.
- Maintain complete, accurate, and concise documentation in electronic laboratory notebooks and other laboratory systems.
- Ensure data and records meet applicable regulatory expectations for global submissions and remain current with relevant industry guidance.
- Author and review study reports, analytical methods, SOPs, technical memos, and other regulatory-compliant documents.
- Communicate bioanalytical results to discovery and development teams; contribute to publications and present findings at scientific meetings.
- Support report quality control, effective time management, and clear cross-functional communication.
- Follow all safety, training, documentation, and site-specific procedural requirements.
- Perform routine laboratory housekeeping and operational support activities as needed.
Requirements
- Doctorate degree OR Master's degree and 2 years of relevant industrial/technical experience OR Bachelor's degree and 4 years of relevant industrial/technical experience
- Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms as well as HRMS
- Prior GLP and GCP experience
- Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, serum, tissues, cerebrospinal fluid)
- Hands-on experience with automated or semi-automated sample preparation for LC-MS bioanalysis, including protein precipitation, SPE, affinity capture, and other high-throughput workflows, using platforms such as KingFisher APEX/FLEX, automated SPE systems, and robotic liquid handlers
- Prior experience in bioanalytical (regulated) assay execution and transfer to CROs
- Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines
- Demonstrated ability to resolve scientific challenges efficiently and prioritize effectively
- Excellent scientific problem-solving skills
- Excellent project and time management abilities
- Ability to work collaboratively with internal and external stakeholders
- Supervisory and mentoring experience in a lab-based setting
Benefits
- Health insurance
- Dental coverage
- Vision coverage
- Retirement and savings plan
- Life insurance
- Disability insurance
- Flexible spending accounts
- Annual bonus program
- Stock-based long-term incentives
- Paid time-off
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.