Scientist – Neuroimmunology Research

The Opportunity

As a Scientist in our Neuroscience and Ophthalmology Discovery team, based at our Roche Innovation Center in Philadelphia, PA (RICP), you will explore how neuroimmunological mechanisms drive neurodegenerative diseases across the central nervous system, peripheral nervous system, and ocular targets. In this lab-based role, you will conceive and execute preclinical studies that advance promising candidates from early target validation through regulatory submission, collaborating with diverse scientific minds to deliver transformative therapies for patients.

• Drive Preclinical Discovery: Conceive, initiate, and execute laboratory research to advance neuroimmunology candidates from target validation to investigational new drug (IND) readiness.
• Lead Laboratory Innovation: Investigate scientific concepts and design cutting-edge in vitro and in vivo disease models to validate novel therapeutic targets and mechanisms.
• Serve as a Scientific Partner: Provide subject matter expertise in neuroimmunology across cross-functional discovery teams, advising on ocular and neurodegenerative research programs.
• Champion Collaboration: Build and manage dynamic research partnerships with global internal teams, academic collaborators, and contract research organizations (CROs).
• Share Knowledge & Insights: Analyze complex experimental datasets, author study reports and regulatory documentation, and present discoveries at international scientific conferences.
• Shape Intellectual Property: Contribute to patent applications and scientific publications that advance the field of neurodegenerative disease research.

Who You Are

You bring curiosity, scientific rigor, and a collaborative mindset to tackling complex biological questions. You thrive at the laboratory bench, communicate ideas with clarity and empathy, and are eager to contribute to an open environment where diverse perspectives spark innovation.

• You hold a PhD in Immunology, Neuroscience, or a closely related biological discipline, paired with at least 2 years of relevant postdoctoral or industry research experience.
• You possess hands-on expertise in advanced immunology laboratory techniques, such as flow cytometry, cell sorting, immunoassays (ELISA, MSD, Western Blotting), and molecular methods (qPCR/ddPCR).
• You demonstrate deep knowledge of neuroimmune biology and experience developing functional cell-based assays for target validation or protein modulation.
• You bring proven experience building and characterizing relevant disease models, including iPSC-derived CNS models is strongly preferred.
• You have a track record of rigorous data analysis and scientific problem-solving.
• You communicate and collaborate effectively within multidisciplinary teams, adapting flexibly to project priorities.