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Scientist, Non-Viral Delivery Process Sciences

Bristol Myers Squibb

Cambridge, MAOnsitePosted 32 days ago$128,380 - $155,571
Full TimeSenior LevelManufacturing & CMCPharmaceutical
Original posting ↗

Summary

We are seeking a highly motivated and technically driven Scientist, Non-Viral Delivery Process Sciences to join BMS's Non-Viral Delivery team and help advance the next frontier in targeted delivery. This role brings together mechanistic process science, experimental innovation, and emerging technologies to build robust, scalable manufacturing strategies for complex non-viral delivery systems. Working at the interface of process science, advanced delivery technologies, and product development, you will make foundational contributions to a rapidly evolving platform and help translate targeted LNP science into scalable process technologies. The ideal candidate thrives in a highly collaborative, multidisciplinary environment and is energized by challenging conventional approaches, accelerating platform innovation, and translating promising scientific advances into development-ready drug products.

Job description

Position Summary

We are seeking a highly motivated and technically driven Scientist, Non-Viral Delivery Process Sciences to join BMS's Non-Viral Delivery team and help advance the next frontier in targeted delivery. This role brings together mechanistic process science, experimental innovation, and emerging technologies to build robust, scalable manufacturing strategies for complex non-viral delivery systems. Working at the interface of process science, advanced delivery technologies, and product development, you will make foundational contributions to a rapidly evolving platform and help translate targeted LNP science into scalable process technologies. The ideal candidate thrives in a highly collaborative, multidisciplinary environment and is energized by challenging conventional approaches, accelerating platform innovation, and translating promising scientific advances into development-ready drug products.

Position Responsibilities

  • Design and execute hypothesis-driven studies to deepen mechanistic process understanding and enable robust, scalable manufacturing approaches for targeted LNP platforms.
  • Develop and optimize end-to-end targeted LNP processes spanning formulation, bioconjugation, purification, and downstream processing, with a focus on scalability, manufacturability, and process robustness.
  • Establish mechanistic process understanding of targeting moiety conjugation and incorporation and how these processes influence product quality attributes.
  • Develop and apply fit-for-purpose scale-down models to support process understanding, sensitivity analysis, and translation to larger-scale manufacturing.
  • Apply design of experiments, statistical analysis, and analytical, biophysical, and functional characterization to establish process–attribute–performance relationships.
  • Partner with Analytical Development to evaluate and implement process analytical technologies to strengthen real-time process understanding.
  • Identify, evaluate, and implement emerging process technologies and experimental approaches that advance targeted LNP development and improve process efficiency, scalability, robustness, and manufacturability.
  • Collaborate cross-functionally across Research, Process Development, Analytical Sciences, CMC, and external partners to translate early process understanding into scalable, development-ready manufacturing approaches.
  • Document and communicate scientific findings through protocols, technical reports, presentations, and multidisciplinary forums.

Basic Qualifications

  • Bachelor's Degree 5+ years of academic and / or industry experience
  • Or Master's Degree 3+ years of academic and / or industry experience
  • Or Ph.D. or equivalent advanced degree in the Life Sciences No experience necessary

Preferred Qualifications

  • PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biochemistry, or a related scientific discipline; or Master's degree with 3+ years or Bachelor's degree with 5+ years of relevant industry experience.
  • Hands-on experience with LNP formulation and relevant unit operations, including rapid mixing (e.g., microfluidic or impingement jet mixing), tangential flow filtration (TFF)/ultrafiltration-diafiltration (UF/DF), purification, or related downstream processing technologies.
  • Experience with bioconjugation, surface functionalization, or related approaches for targeted delivery systems is desirable.
  • Hands-on experience with physicochemical and biophysical characterization of LNPs or related complex drug products using analytical techniques including particle sizing (DLS), zeta potential, UV-Vis and fluorescence spectroscopy, chromatography (e.g., HPLC, LC/MS), electrophoretic methods (e.g., SDS-PAGE), or related approaches.
  • Experience applying design of experiments (DoE), statistical or multivariate analysis, and other data-driven approaches to process development and characterization.
  • Demonstrated ability to work effectively in multidisciplinary teams and thrive in a highly collaborative, cross-functional research environment.
  • Strong technical communication skills, with the ability to present scientific findings and data clearly to multidisciplinary project teams and diverse technical audiences

Requirements

  • Bachelor's Degree with 5+ years of academic and/or industry experience
  • Master's Degree with 3+ years of academic and/or industry experience
  • Ph.D. or equivalent advanced degree in the Life Sciences
  • Hands-on experience with LNP formulation and relevant unit operations
  • Experience with rapid mixing (e.g., microfluidic or impingement jet mixing)
  • Experience with tangential flow filtration (TFF)/ultrafiltration-diafiltration (UF/DF)
  • Experience with purification or related downstream processing technologies
  • Experience with bioconjugation, surface functionalization, or related approaches for targeted delivery systems
  • Hands-on experience with physicochemical and biophysical characterization of LNPs
  • Experience with particle sizing (DLS), zeta potential, UV-Vis and fluorescence spectroscopy
  • Experience with chromatography (e.g., HPLC, LC/MS)
  • Experience with electrophoretic methods (e.g., SDS-PAGE)
  • Experience applying design of experiments (DoE), statistical or multivariate analysis
  • Demonstrated ability to work effectively in multidisciplinary teams
  • Strong technical communication skills

Benefits

  • Health insurance
  • Dental insurance
  • Vision insurance
  • Life insurance
  • Disability insurance
  • Retirement benefits
  • Financial protection benefits
  • Flexible time off
  • Paid company holidays
  • Paid sick leave
  • Volunteer days
  • Summer hours flexibility
  • Global shutdown

Company overview

Bristol Myers Squibb is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. Founded in 1887 and headquartered in Princeton, New Jersey, the company operates with a unique BioPharma strategy that combines the reach and resources of a major pharmaceutical company with the entrepreneurial spirit and agility of a biotech firm. BMS focuses on transformative therapies in key therapeutic areas including oncology, hematology, immunology, cardiovascular disease, and fibrosis. The company has built a sustainable pipeline of potential therapies and leverages translational medicine and data analytics to deliver the right medicine to the right patient at the right time. With over 10,000 employees worldwide, Bristol Myers Squibb maintains a strong commitment to scientific excellence, patient-centric innovation, and global health equity through its foundation. The company's portfolio includes groundbreaking treatments such as Opdivo (nivolumab) for cancer, Eliquis (apixaban) for cardiovascular conditions, and Orencia (abatacept) for autoimmune diseases, among others.

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