Scientist, Non-Viral Gene Editing Platforms
Bristol Myers Squibb
Summary
The Cell Therapy Thematic Research Center is one of BMS's differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. Our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies.
Job description
Position Responsibilities
- Spends a majority of the time working in the lab independently executing experiments and recording detailed ELN entries
- Works diligently within the team to optimize base ex vivo editing platform and implement new technologies for continuous improvement and next-gen in vivo platform development (e.g., lipid nanoparticles)
- Routinely generates CAR-T cells including non-viral gene editing, expansion, and cryopreservation of engineered cells
- Thoroughly characterizes engineered CAR-T cells including phenotypic analysis via flow cytometry, in vitro cytotoxicity assays (e.g., Incucyte), and genomic DNA extraction for downstream molecular analysis
- Independently analyses and interprets experimental data, experience with large and complex datasets a plus
- Actively troubleshoots routine problems and initiatives related to continuous improvement or development of new approaches / technologies
- Proactively communicates and aligns with team members to achieve results and support cross-functional activities
- Generates key data to support decisions that impact the larger team
- Presents findings in multidisciplinary meetings, logically explaining complex scientific concepts and clearly highlighting key messages
- May represent department or team on program/project team or sub-team
Basic Qualifications
- Bachelor's Degree 5+ years of academic and / or industry experience
- Or Master's Degree 3+ years of academic and / or industry experience
- Or Ph.D. or equivalent advanced degree in the Life Sciences
Preferred Qualifications
- Hands-on experience with gene editing technologies (CRISPR/Prime editing preferred)
- Experience with in vivo non-viral gene delivery platforms (including non-cell therapy applications)
- Strong knowledge of molecular biology and prior experience with DNA design tools such as Benchling, Geneious, etc.
- Experience culturing T cells including aseptic technique, T cell activation, and maintenance of primary cell cultures
- Experience with multi-color flow cytometry including complex panel design and multi-parameter data analysis (FlowJo)
- Ability to effectively multi-task, independently organize time, and can develop timelines and deliver results accordingly
- Demonstrated ability to work within a team and thrive in a fast-paced and ever-changing environment
- Detail oriented with excellent verbal and written communication skills and careful documentation (prior ELN experience a plus)
Requirements
- Bachelor's Degree with 5+ years of academic and/or industry experience
- Or Master's Degree with 3+ years of academic and/or industry experience
- Or Ph.D. or equivalent advanced degree in the Life Sciences
- Hands-on experience with gene editing technologies (CRISPR/Prime editing preferred)
- Experience with in vivo non-viral gene delivery platforms
- Strong knowledge of molecular biology
- Experience with DNA design tools such as Benchling, Geneious
- Experience culturing T cells including aseptic technique, T cell activation, and maintenance of primary cell cultures
- Experience with multi-color flow cytometry including complex panel design and multi-parameter data analysis (FlowJo)
- Ability to effectively multi-task, independently organize time, and develop timelines
- Demonstrated ability to work within a team
- Detail oriented with excellent verbal and written communication skills
Benefits
- Wellbeing support
- Retirement benefits
- Financial protection benefits
- Medical, Dental & Vision
- Life & Disability Insurance
- Flexible Time Off
- Paid company holidays
- Paid sick leave
- Paid volunteer days
- Summer hours flexibility
- Leaves of absence
- Annual global shutdown
Company overview
Bristol Myers Squibb is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. Founded in 1887 and headquartered in Princeton, New Jersey, the company operates with a unique BioPharma strategy that combines the reach and resources of a major pharmaceutical company with the entrepreneurial spirit and agility of a biotech firm. BMS focuses on transformative therapies in key therapeutic areas including oncology, hematology, immunology, cardiovascular disease, and fibrosis. The company has built a sustainable pipeline of potential therapies and leverages translational medicine and data analytics to deliver the right medicine to the right patient at the right time. With over 10,000 employees worldwide, Bristol Myers Squibb maintains a strong commitment to scientific excellence, patient-centric innovation, and global health equity through its foundation. The company's portfolio includes groundbreaking treatments such as Opdivo (nivolumab) for cancer, Eliquis (apixaban) for cardiovascular conditions, and Orencia (abatacept) for autoimmune diseases, among others.