Scientist, Pharmacokinetics (Onsite)
Merck
Summary
The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a highly motivated bioanalytical scientist to contribute to our drug discovery and early pre-clinical development efforts. The Scientist will be responsible for execution and troubleshooting of quantitative bioanalytical methods of small molecules, peptides, and large molecules (biologics), utilizing both LC-MS and Ligand Binding Assay (LBA) platforms to deliver high-quality data that drives our pipeline forward.
Job description
Key Responsibilities
- Develop, validate, and execute robust quantitative bioanalytical methods using LC-MS/MS, Ligand Binding Assays (LBA), and/or hybrid LC-MS/LBA workflows to support discovery and early development programs.
- Generate, analyze, and deliver high-quality bioanalytical data for PK, PD, and in vitro studies of both small and large molecule therapeutics within established timelines.
- Perform manual and automated sample preparation (e.g., protein precipitation, solid-phase extraction, immunocapture/affinity purification for biological matrices).
- Maintain laboratory equipment and ensure all operations strictly adhere to safety, internal SOPs, and regulatory guidelines.
- Support high-throughput workflows by operating and troubleshooting robotics and automated systems.
Education Minimum Requirement
Bachelor's degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience) in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field.
Required Experience & Skills
- Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics.
- Demonstrated ability to collaborate effectively within high-performing, multidisciplinary scientific teams.
- Excellent written and verbal communication skills, with the ability to present scientific data clearly.
- Proficient in Microsoft Office Suite (Excel, Word, PowerPoint) and standard laboratory software.
Preferred Skills
- A basic understanding of statistical analysis and pharmacokinetic principles.
- Experience with liquid chromatography (LC) and mass spectrometry (MS) for the quantitative analysis of small molecules and/or peptides in biological matrices.
Requirements
- Bachelor's degree with 3+ years relevant laboratory experience or MS degree with 1-2 years relevant experience in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field
- Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics
- Demonstrated ability to collaborate effectively within multidisciplinary scientific teams
- Excellent written and verbal communication skills
- Proficient in Microsoft Office Suite (Excel, Word, PowerPoint) and standard laboratory software
Benefits
- Medical, Dental & Vision
- 401(k) Matching
- Paid Holidays
- Vacation
- Sick Leave
- Annual Bonus
- Long-Term Incentive
Company overview
Merck & Co., Inc., known as Merck in the United States and Canada and MSD (Merck Sharp & Dohme) internationally, is a premier American multinational pharmaceutical company headquartered in Rahway, New Jersey. Founded in 1891 as the U.S. subsidiary of the German Merck Group, the company became independent following World War I and has since grown into one of the world's largest biomedical companies, ranking fourth globally by revenue. Merck operates across three core business segments: pharmaceuticals, vaccines, and animal health products. The company is renowned for its groundbreaking research and development, having brought numerous life-saving medicines to market including Keytruda (pembrolizumab), a leading immunotherapy for cancer treatment that generated $29.5 billion in 2024 revenue, and Gardasil, a revolutionary HPV vaccine. With approximately 75,000 employees worldwide, Merck maintains a robust pipeline of innovative therapies focused on oncology, vaccines, hospital acute care, cardiology, neuroscience, virology, immunology, and diabetes. The company invests heavily in R&D, spending $17.9 billion in 2024 alone, demonstrating its commitment to advancing scientific discovery. Merck's legacy spans over 130 years of bringing hope to humanity through important medicines and vaccines, operating with a purpose to use leading-edge science to save and improve lives globally while fostering an inclusive workforce and responsible business practices.