Scientist, Pharmacokinetics (Onsite)
MSD
Summary
The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a highly motivated bioanalytical scientist to contribute to our drug discovery and early pre-clinical development efforts. The Scientist will be responsible for execution and troubleshooting of quantitative bioanalytical methods of small molecules, peptides, and large molecules (biologics), utilizing both LC-MS and Ligand Binding Assay (LBA) platforms to deliver high-quality data that drives our pipeline forward.
Job description
Key Responsibilities
- Develop, validate, and execute robust quantitative bioanalytical methods using LC-MS/MS, Ligand Binding Assays (LBA), and/or hybrid LC-MS/LBA workflows to support discovery and early development programs.
- Generate, analyze, and deliver high-quality bioanalytical data for PK, PD, and in vitro studies of both small and large molecule therapeutics within established timelines.
- Perform manual and automated sample preparation (e.g., protein precipitation, solid-phase extraction, immunocapture/affinity purification for biological matrices).
- Maintain laboratory equipment and ensure all operations strictly adhere to safety, internal SOPs, and regulatory guidelines.
- Support high-throughput workflows by operating and troubleshooting robotics and automated systems.
Education Minimum Requirement
Bachelor's degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience) in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field.
Required Experience & Skills
- Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics.
- Demonstrated ability to collaborate effectively within high-performing, multidisciplinary scientific teams.
- Excellent written and verbal communication skills, with the ability to present scientific data clearly.
- Proficient in Microsoft Office Suite (Excel, Word, PowerPoint) and standard laboratory software.
Preferred Skills
- A basic understanding of statistical analysis and pharmacokinetic principles.
- Experience with liquid chromatography (LC) and mass spectrometry (MS) for the quantitative analysis of small molecules and/or peptides in biological matrices.
Requirements
- Bachelor's degree with 3+ years relevant laboratory experience or MS degree with 1-2 years relevant experience in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field
- Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics
- Demonstrated ability to collaborate effectively within multidisciplinary scientific teams
- Excellent written and verbal communication skills
- Proficient in Microsoft Office Suite and standard laboratory software
Benefits
- Medical, Dental & Vision
- 401(k) Matching
- Retirement Benefits
- Paid Holidays
- Vacation
- Compassionate & Sick Days
- Annual Bonus
- Long-Term Incentive
Company overview
MSD, known as Merck Sharp & Dohme outside the United States and Canada, is a global research-intensive biopharmaceutical company headquartered in Rahway, New Jersey. Founded in 1891, the company has established itself as one of the world's leading pharmaceutical corporations with a rich history spanning over 130 years. MSD operates as the international division of Merck & Co., Inc., focusing on the discovery, development, manufacturing, and marketing of innovative medicines, vaccines, biologic therapies, and animal health products. The company's extensive portfolio includes groundbreaking treatments in oncology, infectious diseases, cardiology, diabetes, and vaccines, with notable products such as Keytruda (pembrolizumab) for cancer immunotherapy, Gardasil for HPV prevention, and Januvia for diabetes management. MSD maintains a strong commitment to research and development, investing significantly in scientific innovation to address unmet medical needs worldwide. With approximately 75,000 employees globally, the company operates through four main segments: pharmaceuticals, animal health, healthcare services, and strategic alliances. MSD's mission centers on using leading-edge science to save and improve lives around the world, guided by the principle that medicine is for people, not profits.