Scientist, Proteins, Analytical Development
Johnson & Johnson Innovative Medicine
Summary
The Therapeutics, Development & Supply (TDS), Proteins Analytical Development (AD) is recruiting for a Scientist who will conduct peptide mapping method development and qualification activities on monoclonal antibodies, bi- and tri-specific antibodies and antibody drug conjugates.
Job description
Purpose
The Therapeutics, Development & Supply (TDS), Proteins Analytical Development (AD) is recruiting for a Scientist who will conduct peptide mapping method development and qualification activities on monoclonal antibodies, bi- and tri-specific antibodies and antibody drug conjugates.
Responsibilities
- Operate state-of-the-art LC and MS instrumentation
- Learn and apply different software packages for LCMS/protein analysis
- Perform LCMS-based quantitation of post-translational modifications
- Design and implement peptide mapping / MS experiments on antibodies and recombinant proteins to assess sequence coverage and sites of modification
- Participate in IND, IMPD, BLA, and other regulatory filings
- Develop test methods, provide documentation and write scientific reports
- Conduct testing to support analytical development, manufacturing process development, process validations, and manufacturing investigations
- Lead or facilitate technical discussions and participate in cross-functional teams at project-related meetings
Qualifications / Requirements
Education: A master's degree with 5+ years, or a bachelor's degree with 9+ years of relevant biochemical experience.
Required
- Proven scientific expertise with extensive hands-on experience with LC-MS
- Knowledge of method robustness, method design and familiarity with assay validation parameters
- Excellent organization, communication, presentation skills and scientific/technical writing skills
- Proficiency at running and trouble-shooting assays
- Able to manage multiple tasks, handle tight timelines and deliver quality data
Preferred
- Experience peptide mapping method development and qualification activities on monoclonal antibodies, bi- and tri-specific antibodies and antibody drug conjugates
- Excellent interpersonal skills
- Experience with commercialization of therapeutic proteins
- An understanding and experience in the application of various GXP concepts
- Experience preparing reports, protocols and SOPs
Requirements
- Master's degree with 5+ years, or bachelor's degree with 9+ years of relevant biochemical experience
- Proven scientific expertise with extensive hands-on experience with LC-MS
- Knowledge of method robustness, method design and familiarity with assay validation parameters
- Excellent organization, communication, presentation skills and scientific/technical writing skills
- Proficiency at running and trouble-shooting assays
- Able to manage multiple tasks, handle tight timelines and deliver quality data
- Preferred: Experience peptide mapping method development and qualification activities on monoclonal antibodies, bi- and tri-specific antibodies and antibody drug conjugates
- Preferred: Excellent interpersonal skills
- Preferred: Experience with commercialization of therapeutic proteins
- Preferred: An understanding and experience in the application of various GXP concepts
- Preferred: Experience preparing reports, protocols and SOPs
Company overview
Johnson & Johnson Innovative Medicine is the pharmaceutical division of Johnson & Johnson, leading the way in medical innovation with a relentless focus on bringing transformational treatments to patients worldwide. The company applies rigorous science and compassion to address the most complex diseases of our time, developing groundbreaking medicines across key therapeutic areas including oncology, immunology, neuroscience, and cardiopulmonary medicine. With deep expertise and global reach, Johnson & Johnson Innovative Medicine reimagines how devastating diseases are treated and cured, delivering hope and better care for millions of patients and their families. The organization pioneers the path from laboratory research to clinical application, championing patients every step of the way while maintaining an unwavering commitment to scientific excellence and patient-centered innovation.