Scientist, R&D Chemistry, Peptidomimetic Purification
Regeneron Pharmaceuticals
Summary
We are currently seeking a lab-centric peptide purification chemist to join the R&D Chemistry group. In this position, they will play a key role in Regeneron's peptidomimetic antibody-conjugate drug discovery capabilities to enable seamless combination with the company's existing expertise in biologics and novel genetic medicines. The candidate will drive the purification of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas.
Job description
Discover Your Role
- Actively participate and collaborate in the day-to-day activities of the R&D Chemistry Peptidomimetic purification team.
- Perform mass-triggered HPLC purification of novel peptidomimetic drug modalities, using modern purification instrumentation/detection and techniques.
- Troubleshoot and optimize peptide purification methods and enable high throughput purification and isolation.
- Identify new strategies and technologies for peptidomimetic purification to improve on existing Regeneron techniques.
- Actively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic purification team.
- Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.
This role requires:
- Bachelor's degree required, Master's degree preferred in peptide, peptidomimetic, small molecule purification.
- Minimum of 5 years of industry experience.
- Extensive hands-on experience of the HPLC purification/detection and method troubleshooting of peptidomimetics.
- Hands-on experience with Waters and/or Agilent purifications systems preferred.
- Hands-on experience with mass-triggered collection preferred.
- Experience with high throughput purification.
- Extensive experience running modern purification/isolation equipment and instrumentation.
- A track record of success in the field of either peptidomimetics or small molecules purification is required.
- Working collaboratively with both internal and external organizations (e.g., CROs) is essential.
Requirements
- Bachelor's degree required in peptide, peptidomimetic, or small molecule purification
- Master's degree preferred
- Minimum of 5 years of industry experience
- Extensive hands-on experience of HPLC purification/detection and method troubleshooting of peptidomimetics
- Hands-on experience with Waters and/or Agilent purification systems preferred
- Hands-on experience with mass-triggered collection preferred
- Experience with high throughput purification
- Extensive experience running modern purification/isolation equipment and instrumentation
- Track record of success in peptidomimetics or small molecules purification
- Working collaboratively with internal and external organizations (e.g., CROs)
Benefits
- Annual bonuses
- Incentive plans
- Equity awards
- Pension or retirement benefits
- 401(k) company match
- Health and wellness programs
- Fitness centers
- Insurance benefits
- Paid time off
- Family support benefits
Company overview
Regeneron Pharmaceuticals is a leading American biotechnology company founded in 1988 and headquartered in Tarrytown, New York. The company specializes in inventing, developing, and commercializing life-transforming medicines for people with serious diseases. Regeneron is renowned for its innovative antibody technologies and has developed several groundbreaking therapies, including EYLEA® for retinal diseases, DUPIXENT® for inflammatory conditions, and the COVID-19 antibody cocktail REGEN-COV®. The company operates with a strong focus on research and development across multiple therapeutic areas including ophthalmology, oncology, cardiovascular diseases, and rare genetic disorders. Regeneron's proprietary VelocImmune® technology platform enables the rapid generation of fully human monoclonal antibodies. With over 15,000 employees globally and annual revenues exceeding $14 billion, Regeneron has established itself as a major force in the biotechnology industry, consistently ranking among the top-performing pharmaceutical companies and maintaining a robust pipeline of investigational therapies.