Scientist - Tissue Engineering, GLACED

Who You Are

The successful candidate will drive process optimization through experimental design, data analysis, and technology transfer activities, while ensuring scientific rigor, documentation accuracy, and alignment with regulatory and quality requirements.

This role will play a critical part in advancing recellularization platforms from research and development through process characterization and clinical manufacturing readiness. Lead, develop and perform hands-on design, optimization, and execution of lung scaffold recellularization experiments using iPSC-derived cells, and drive continuous improvement of recellularization methods.

• Prepare organs, tissues, and cells for experimentation using appropriate surgical handling techniques, dissection, cannulation, and suturing
• Develop new techniques, laboratory procedures and protocols as indicated to support lung scaffold recellularization and characterization efforts using iPSC derived cells
• Develop strategies to seed multiple iPSC derived cell types into lung scaffolds
• Evaluate the vascular integrity (vascular leak, blood perfusion, etc.) of lung tissues, including native lungs, decellularized lung scaffolds, and tissue engineered lung constructs
• Apply and adapt existing assays to evaluate cell phenotype and function on scaffolds recellularized with iPSC-derived cells
• Routinely perform molecular and cell biology assays to evaluate cell distribution and cell phenotype in recellularized scaffolds
• Analyze and integrate data from multiple components of the recell process to draw conclusions for improvements to strategy development
• Coordinate shipment of samples for outsourced testing
• Maintain data integrity and a well-run laboratory by following Good Documentation Practices (GDP) and GLP-like standards, including accurate, contemporaneous recording of all data in the in-house system(s) and keeping the lab clean, organized, and safe
• Record and manage use of materials and reagents needed to carry out experiments
• Follow proper procedures regarding laboratory safety, use of personal protective equipment, and handling of biohazard materials, including human or animal cells and tissues
• Supervise/lead/mentor laboratory personnel and team members as required for specific tasks
• Collaborate closely with the iPSC production and differentiation team to align cell supply, quality, and timelines with recellularization needs, and with the process development team to adapt and optimize existing recellularization protocols for iPSC-derived cells
• Manage day-to-day laboratory operations, including housekeeping, inventory and ordering of materials and reagents, and equipment upkeep, so the lab stays clean, organized, safe, and fully supplied
• Direct and manage direct reports to include responsibilities for training, goal setting & achievement, performance evaluations/management, coaching, mentoring, career development and provide support for recruitment process (as needed)
• Perform other duties as assigned