
Self Healing Supply Chain Senior Director
AstraZeneca
Summary
Lead one of the most aspiring AI-driven supply chain transformations in the industry as Senior Director of the Self-Healing Supply Chain program, shaping how a global biopharmaceutical supply chain senses disruption, makes better decisions and learns from every outcome.
Job description
The Self-Healing Supply Chain (SHSC) program follows a Sense, Assess, Heal and Learn loop, using AI and end-to-end enterprise data to detect issues, assess impact, simulate scenarios, recommend actions and learn from outcomes. It brings together Decision Intelligence, a supply chain digital twin and knowledge graph, risk sensing and an AI-powered supply chain assistant, with control tower capabilities in development.
Reporting to the Executive Director, Digital Supply Chain, you will lead a multi-location core team of Decision Architects, workstream leads and change and communications specialists, and direct a wider delivery network across IT, data, business services and external partners.
What you'll do
- Set the SHSC vision, strategy and decision roadmap, defining which decisions to support, augment or automate, and the right level of autonomy for each; lead annual integrated planning to deliver one prioritized, resourced portfolio.
- Lead day-to-day program management and line-manage the core team; chair steering committees, integrated plan reviews and quarterly benefit reviews; lead a fixed-capacity delivery model.
- Steer the Decision Architecture discipline so every use case starts from a clearly defined business decision; shape the roadmap for the Decision Intelligence platform, including controlled write-back to ERP and planning systems and progression from human-in-the-loop to human-on-the-loop automation.
- Implement a governed intake, assessment and prioritization process with clear decision gates; build business cases and track benefits through accountable business owners, measuring adoption as well as delivery.
- Grow internal Decision Architecture capability through secondments and a common accreditation pathway; guide the move from partner-led delivery to internal ownership.
- Build trusted relationships with senior leaders, business functions and strategic technology partners, owning partner performance, commercial value and knowledge transfer.
- Maintain risk and KPI frameworks, lead critical dependencies such as ERP transformation, data readiness and integration architecture, and apply risk-based human oversight suited to a GxP-regulated environment.
- Redesign roles, routines and decision rights so planners move from collecting data to managing exceptions; build trust through explainable recommendations and transfer mature capabilities into business ownership.
Essential for the role
- Bachelor's Degree
- 10+ years leading large-scale digital transformation programs with cross-functional teams, ideally in supply chain planning or logistics
- Deep understanding of end-to-end supply chain operations and business processes, ideally in a complex, regulated manufacturing environment
- Experience in decision-centric design (Decision Architecture), breaking complex operational decisions into triggers, logic, trade-offs and guardrails
- Experience leading Decision Intelligence or AI-enabled decision portfolios from MVP to scale-up and business-as-usual operation, including human-in/on-the-loop governance and write-back to ERP and planning systems
- Management-level experience of digital supply chain platforms (e.g., ERP, APS) and a record of effective partnership with IT
- Track record of building internal capability, moving delivery from external partners to business ownership, and shaping data and architecture demand
- Experience with decision intelligence platforms
Desirable for the role
- MBA degree
- Pharmaceutical or healthcare industry experience, including the regulatory environment
- Experience in a global role handling international supply chain challenges
- Proficiency in Agile methods and structured project management frameworks
- Familiarity with supply chain technologies such as OMP, SAP (including S/4HANA), Resilinc, project44, One Network, Celonis, Neo4j knowledge graphs and Optilogic
Requirements
- Bachelor's Degree
- 10+ years leading large-scale digital transformation programs with cross-functional teams, ideally in supply chain planning or logistics
- Deep understanding of end-to-end supply chain operations and business processes, ideally in a complex, regulated manufacturing environment
- Experience in decision-centric design (Decision Architecture), breaking complex operational decisions into triggers, logic, trade-offs and guardrails
- Experience leading Decision Intelligence or AI-enabled decision portfolios from MVP to scale-up and business-as-usual operation, including human-in/on-the-loop governance and write-back to ERP and planning systems
- Management-level experience of digital supply chain platforms (e.g., ERP, APS) and a record of effective partnership with IT
- Track record of building internal capability, moving delivery from external partners to business ownership, and shaping data and architecture demand
- Experience with decision intelligence platforms
- MBA degree (desirable)
- Pharmaceutical or healthcare industry experience, including the regulatory environment (desirable)
- Experience in a global role handling international supply chain challenges (desirable)
- Proficiency in Agile methods and structured project management frameworks (desirable)
- Familiarity with supply chain technologies such as OMP, SAP (including S/4HANA), Resilinc, project44, One Network, Celonis, Neo4j knowledge graphs and Optilogic (desirable)
Benefits
- Qualified Retirement Programs
- Paid Time Off
- Health Coverage
- Dental Coverage
- Vision Coverage
- Short-Term Incentive Bonuses
- Equity-Based Awards
Company overview
AstraZeneca is a global, science-led, patient-focused pharmaceutical company dedicated to accelerating the delivery of life-changing medicines that create enduring value for patients, society, and shareholders. With a workforce of over 94,300 employees worldwide, the company operates across three core therapy areas: Oncology, BioPharmaceuticals (including Cardiovascular, Renal & Metabolism, Respiratory & Immunology), and Rare Disease. Headquartered in Cambridge, UK, AstraZeneca maintains strategic R&D centers in Cambridge, Gaithersburg (US), Boston (US), Gothenburg (Sweden), Shanghai, and Beijing. The company generated $54.1 billion in total revenue in 2024 and invested $13.6 billion in scientific research and development. AstraZeneca's bold aspiration is to be pioneers in science, lead in disease areas, and transform patient outcomes, with a goal to launch 20 new medicines and achieve $80 billion in total revenue by 2030. The company is recognized for its commitment to sustainability, health equity, and creating an inclusive work environment where diverse perspectives drive innovation.