Senior Associate Scientist In vitro Biology Neuroscience Discovery

We are seeking a creative and rigorous scientist to investigate novel therapeutic targets and build confidence in their relevance to neurodegenerative disease. The successful candidate will develop and apply disease-relevant assays and advanced human iPSC-based models to understand how genetic or pharmacologic target modulation influences disease biology.

Position Responsibilities

• Design and execute hypothesis-driven studies to investigate novel therapeutic targets in neurodegenerative disease.
• Develop and apply advanced human iPSC-based models and disease-relevant assays to evaluate target biology and therapeutic potential.
• Design, optimize, and implement mechanistic and translational assays that enable target interrogation, in vitro pharmacological characterization, compound profiling, and progression of drug-discovery programs.
• Establish causal relationships between target modulation and disease-relevant mechanisms using genetic, pharmacological, and molecular approaches.
• Support structure-activity relationship (SAR) efforts by generating high-quality in vitro pharmacology data that inform compound optimization, mechanism-of-action studies, and program progression.
• Represent Discovery Biology on cross-functional program teams, presenting experimental results and biological interpretation to support program progression.

Basic Qualifications

• Bachelor's degree with 4+ years of academic and/or industry experience or Master's degree with 2+ years of academic and/or industry experience

Preferred Qualifications

• Degree in neuroscience, biology, molecular biology, cell biology, or a related discipline.
• Strong foundation in molecular and cellular biology, with experience designing and executing experiments to address biological questions.
• Experience developing and applying cellular assays for target validation, pharmacological characterization, and/or compound profiling.
• Hands-on experience with human iPSC-derived neural and/or glial models and their application to neurodegenerative disease research.
• Demonstrated ability to independently drive experiments from conception through data interpretation and clearly present scientific findings within multidisciplinary teams.

Additional Preferred Qualifications and Experience

• Strong understanding of neurodegenerative disease biology, including pathways related to mitochondrial function, neuroinflammation, lipid and lysosomal biology, and protein homeostasis.
• Experience developing and applying robust cellular assays for target validation, pharmacological characterization, or compound profiling.
• Experience with disease-relevant cellular models and phenotypic endpoints applicable to neurodegenerative disease.
• Industry experience supporting target validation, in vitro pharmacology, or drug-discovery programs is beneficial.