Senior Associate Scientist, Synthesis, RNA Process Sciences
Bristol Myers Squibb
Summary
The RNA Synthesis Process Sciences role plays a central part in collaborating with research and manufacturing to define early process conditions and scale down process development. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline. The Senior Associate Scientist provides scientific support for drug substance programs spanning preclinical to early-stage development across circular and linear mRNA modalities. This role encompasses hands-on contributions by driving sound experimental execution and establishing linkages from a research concept to manufacturing implementation. The candidate should be driven by developing and characterizing RNA synthesis processes for improving the yield, quality and robustness.
Job description
Position Summary
The RNA Synthesis Process Sciences role plays a central part in collaborating with research and manufacturing to define early process conditions and scale down process development. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline. The Senior Associate Scientist provides scientific support for drug substance programs spanning preclinical to early-stage development across circular and linear mRNA modalities. This role encompasses hands-on contributions by driving sound experimental execution and establishing linkages from a research concept to manufacturing implementation. The candidate should be driven by developing and characterizing RNA synthesis processes for improving the yield, quality and robustness.
Key Responsibilities
- Apply high throughput and data driven approaches to perform early optimization and characterization of in vitro transcription, circularization and DNase reactions
- Support the RNA drug substance synthesis process definition and scale up
- Experiment using high throughput/automated or data rich experimental setups
- Support experiments to confirm robust process performance across the control space
- Collaborate with research teams to enable quicker transitions from drug candidate nomination to clinical manufacturing
- Prepare sections of technical reports, and communicate findings internally as appropriate
- Participate in tech transfer activities to GMP manufacturing sites for RNA programs
Qualifications & Experience
- Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
- BS with 4+ years’ experience in science related disciplines
- MS with 2+ years’ experience in science related disciplines
- Knowledge of automated liquid handlers, small scale stir tank reactors, and other novel reactor designs
- Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
- Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
- Hands-on experience programming/operating liquid handling systems, high throughput workflow design, LIMS/ELN systems for sample tracking, and scripting languages for instrument control is a plus
- Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing is a plus
- Background in providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications is a plus
- Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
- Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus
Requirements
- Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
- BS with 4+ years’ experience in science related disciplines
- MS with 2+ years’ experience in science related disciplines
- Knowledge of automated liquid handlers, small scale stir tank reactors, and other novel reactor designs
- Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
- Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
Benefits
- Wellbeing support
- Retirement benefits
- Financial protection benefits
- Medical insurance
- Dental insurance
- Vision insurance
- Life insurance
- Disability insurance
- Flexible Time Off
- Paid company holidays
- Paid sick leave
- Paid volunteer days
- Summer hours flexibility
- Leaves of absence
- Annual Global Shutdown
Company overview
Bristol Myers Squibb is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. Founded in 1887 and headquartered in Princeton, New Jersey, the company operates with a unique BioPharma strategy that combines the reach and resources of a major pharmaceutical company with the entrepreneurial spirit and agility of a biotech firm. BMS focuses on transformative therapies in key therapeutic areas including oncology, hematology, immunology, cardiovascular disease, and fibrosis. The company has built a sustainable pipeline of potential therapies and leverages translational medicine and data analytics to deliver the right medicine to the right patient at the right time. With over 10,000 employees worldwide, Bristol Myers Squibb maintains a strong commitment to scientific excellence, patient-centric innovation, and global health equity through its foundation. The company's portfolio includes groundbreaking treatments such as Opdivo (nivolumab) for cancer, Eliquis (apixaban) for cardiovascular conditions, and Orencia (abatacept) for autoimmune diseases, among others.