Senior Cytogenetics Technologist - Genomic Stability

About you

You're a careful, hands-on technologist who takes pride in high-quality chromosome preparations and confident karyotype calls. You are comfortable bringing an established cytogenetics workflow into a new laboratory environment—setting up the process, confirming that it performs consistently, documenting it clearly, and troubleshooting issues as they arise. You're at home at the microscope and equally happy in a tissue-culture hood keeping iPSC lines healthy. You're collaborative, easy-going, proactive in how you communicate, and flexible about scheduling when the culture rotation calls for it.

What you'll do in this role

• Transfer in, implement, and document an established G-banding and karyotyping workflow in-house for HSC program cell products.
• Execute the full cytogenetics workflow (initially in research/PD and then in our GMP suite): metaphase arrest, cell harvest, hypotonic treatment, slide preparation, fixation, Giemsa staining, metaphase imaging, and software-assisted karyotype analysis.
• Compare initial in-house results against historical data and document appropriate operating and quality-control criteria.
• Analyze metaphase spreads to identify numerical and structural chromosomal abnormalities, and document findings clearly.
• Support genomic-stability assessment of human primary cells
• Culture, passage, expand, bank, and prepare iPSC samples in preparation for karyotyping
• Track clone-level genomic stability, passage number, culture conditions, and QC status across lines.
• Coordinate with CROs shipments of samples for genomic instability analysis
• Maintain organized records, sample tracking, and imaging files, and develop SOPs for the workflows you build.

You might thrive in this role if you

• Have several years of hands-on G-banding and karyotype analysis experience, with demonstrated ability to make independent chromosome assessments and troubleshoot chromosome preparation and image quality.
• Have experience with imaging software such as MetaSystems / Ikaros or Cytovision.
• Have hands-on mammalian cell culture experience with strong sterile technique.
• Are comfortable with high-magnification microscopy.
• Are highly organized and able to run multiple clone/sample workflows in parallel.
• Are available for weekend work as part of a team rotation.

Bonus if you

• Have experience standing up or validating a new assay in-house.
• Hold current CG(ASCP) certification in cytogenetics.
• Hold a Bachelor's or Master's degree in cell biology, molecular biology, cytogenetics, genetics, stem cell biology, biomedical sciences, or a related field.
• Have hands-on experience maintaining iPSC cultures.