Senior Director, Clinical Pharmacology
Bristol Myers Squibb
Summary
The Senior Director, Clinical Pharmacology provides strategic and scientific leadership for clinical pharmacology activities across drug development programs. This role leads the planning and execution of clinical pharmacology strategies, including PK/PD and model-informed drug development approaches, and oversees development and delivery of Clinical Pharmacology & Pharmacometrics plans aligned with compound strategy. The Senior Director serves as a key member of Clinical Pharmacology leadership and cross-functional program teams, influencing development strategy and decision-making while fostering a collaborative, high-performing learning environment.
Job description
Position Summary
The Senior Director, Clinical Pharmacology provides strategic and scientific leadership for clinical pharmacology activities across drug development programs. This role leads the planning and execution of clinical pharmacology strategies, including PK/PD and model-informed drug development approaches, and oversees development and delivery of Clinical Pharmacology & Pharmacometrics plans aligned with compound strategy. The Senior Director serves as a key member of Clinical Pharmacology leadership and cross-functional program teams, influencing development strategy and decision-making while fostering a collaborative, high-performing learning environment.
Key Responsibilities
- Manage and mentor other CP&P leads as appropriate
- Responsible and accountable for clinical pharmacology strategy across all phases of development
- Represent the ClinPharm department on cross-functional disease strategy teams and on relevant governance forums
- Provide input to Phase 2/3 clinical study design and registrational strategy
- Supervise the development of the Clinical Pharmacology Plan(s)
- Supervise design of Clinical Pharmacology studies and manages data analysis, interpretation, and reporting
- Drive decision-making and strategy over the entire portfolio or critical portions of the portfolio of compounds, through effective partnership with senior leaders
- High proficiency in PK, PK/PD, and model informed drug development (MIDD) principles and analyses
- Lead collaboration on cross-functional drug development teams, regulatory submissions, and departmental initiatives; serves as Clinical Pharmacology subject matter expert
- Represent department in interactions with health authorities; serve as Clinical Pharmacology subject matter expert
- Oversee internal initiatives and serves as department representative on external initiatives
- Work with Business Development teams and provide critical expertise to assess external acquisitions
- Responsible for administrative deliverables such as creating Therapeutic area level departmental objectives, hiring / retaining talent, maintaining budgets, etc.
Qualifications & Experience
- MS, PhD or PharmD in relevant field or a PharmD with post-doctoral training
- Approximately 10+ years' experience with demonstrated progression in Clinical Pharmacology and Pharmacometrics, including extensive expertise in the general drug development process and in small molecule and/or biologic drug property characterization
- In-depth knowledge of current practices and issues in Clinical Pharmacology and Pharmacometrics
- Strong written and oral communication skills necessary to report on and deliver scientific presentations
- Demonstrated ability to work in a dynamic team-oriented environment
- Manage a team of CP&P scientists and provide mentorship and guidance to staff and CP&P function
- Independently serve as the CP&P lead for one or more assets in the BMS drug development program
- Demonstrated leadership abilities, expanded sphere of influence, and stakeholder management in a matrix environment
- Programming experience is highly desired (e.g., NONMEM, R, and WinNonlin. SAS, Splus, etc.)
- Quantitative data analysis, POP PK/PD, and data visualization skills are highly desired
Requirements
- MS, PhD or PharmD in relevant field or a PharmD with post-doctoral training
- Approximately 10+ years' experience with demonstrated progression in Clinical Pharmacology and Pharmacometrics
- Extensive expertise in the general drug development process and in small molecule and/or biologic drug property characterization
- In-depth knowledge of current practices and issues in Clinical Pharmacology and Pharmacometrics
- Strong written and oral communication skills necessary to report on and deliver scientific presentations
- Demonstrated ability to work in a dynamic team-oriented environment
- Manage a team of CP&P scientists and provide mentorship and guidance to staff and CP&P function
- Independently serve as the CP&P lead for one or more assets in the BMS drug development program
- Demonstrated leadership abilities, expanded sphere of influence, and stakeholder management in a matrix environment
- Programming experience is highly desired (e.g., NONMEM, R, and WinNonlin. SAS, Splus, etc.)
- Quantitative data analysis, POP PK/PD, and data visualization skills are highly desired
Benefits
- Wellbeing Support
- Retirement Benefits
- Financial Protection Benefits
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Life Insurance
- Disability Insurance
- Flexible Time Off
- Paid Company Holidays
- Paid Sick Leave
- Volunteer Days
- Summer Hours Flexibility
- Leaves of Absence
- Annual Global Shutdown
Company overview
Bristol Myers Squibb is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. Founded in 1887 and headquartered in Princeton, New Jersey, the company operates with a unique BioPharma strategy that combines the reach and resources of a major pharmaceutical company with the entrepreneurial spirit and agility of a biotech firm. BMS focuses on transformative therapies in key therapeutic areas including oncology, hematology, immunology, cardiovascular disease, and fibrosis. The company has built a sustainable pipeline of potential therapies and leverages translational medicine and data analytics to deliver the right medicine to the right patient at the right time. With over 10,000 employees worldwide, Bristol Myers Squibb maintains a strong commitment to scientific excellence, patient-centric innovation, and global health equity through its foundation. The company's portfolio includes groundbreaking treatments such as Opdivo (nivolumab) for cancer, Eliquis (apixaban) for cardiovascular conditions, and Orencia (abatacept) for autoimmune diseases, among others.