Senior Director, Clinical Science, Immunology, Hybrid

Role Overview

The Senior Director, Clinical Science, Immunology provides strategic Clinical Science leadership across multiple studies, programs, and assets, reporting to the Executive Director. The role contributes to disease area strategy by applying deep therapeutic expertise to guide Clinical Science approaches, support development planning, and promote consistency in scientific standards, medical data review practices, and decision-making across the portfolio.

Key Responsibilities

• Provide strategic Clinical Science leadership across the disease area, including multiple studies, programs, and assets.
• Contribute to disease area strategy with input on development opportunities, scientific considerations, portfolio risks, and implications of emerging data.
• Partner with Section Heads, Asset Leads, Program Development Team Leads, and cross-functional leaders to align Clinical Science activities with program and disease area objectives.
• Apply expert knowledge of disease biology, treatment landscape, and clinically meaningful endpoints to inform study planning, data interpretation, and issue resolution.
• Lead efforts to standardize Clinical Science approaches, including medical data review practices, data interpretation principles, and key deliverables.
• Promote consistency in Clinical Science activities across studies and programs while allowing for program-specific needs.
• Advocate for innovative approaches including visual analytics, centralized data review, AI-enabled workflows, and other technologies.
• Provide senior scientific guidance across assigned studies and programs to support high-quality Clinical Science input.
• Guide interpretation of clinical data across studies, cohorts, and assets to support understanding of trends, opportunities, risks, and program implications.
• Contribute scientific perspective to protocol development, amendments, study design, endpoint selection, eligibility criteria, biomarker strategy, and development planning.
• Contribute Clinical Science perspective to portfolio discussions, governance reviews, and senior leadership meetings.
• Support preparation of clinical and scientific content for governance discussions, program reviews, and senior management communications.
• Translate portfolio priorities into Clinical Science strategies, capabilities, and resource plans.
• Provide direct management for Directors, Principal Scientists, and Clinical Scientists as appropriate.
• Support development of Clinical Science talent through coaching, mentoring, feedback, and development opportunities.
• Foster a culture of accountability, inclusion, continuous learning, and strong team performance.
• Partner closely with Clinical Operations, Regulatory Affairs, Biostatistics, Data Management, Drug Safety and Pharmacovigilance, Translational Medicine, Medical Affairs, and other functions.
• Ensure Clinical Science activities comply with regulatory requirements, company policies, and established procedures.
• Support inspection readiness and documentation of Clinical Science contributions.
• Identify opportunities to improve quality, consistency, and effectiveness of Clinical Science work.

Qualifications, Skills & Experience

• Advanced scientific or healthcare degree required (e.g., PhD, PharmD), or equivalent, and 8+ years of pharmaceutical, clinical drug development, and/or medical field experience preferred; OR Master’s degree preferably in life sciences and 12+ years of experience; OR Bachelor’s degree preferably in life sciences and 15+ years of experience.
• Significant experience in Clinical Development, Clinical Science, clinical drug development, or a related function within the pharmaceutical or biotechnology industry.
• Demonstrated experience providing Clinical Science leadership across multiple studies, programs, or assets.
• Deep therapeutic area expertise, including disease biology, current and emerging treatment landscape, clinically relevant endpoints, and key scientific considerations affecting development.
• Strong understanding of clinical trial design, clinical development strategy, clinical data review, and interpretation of oncology data.
• Experience contributing to disease area strategy, portfolio discussions, or cross-program planning.
• Experience contributing to regulatory submissions, safety reviews, or health authority interactions.
• Experience working effectively in cross-functional teams within a matrix environment.
• Demonstrated ability to integrate information across studies and programs to support scientific and business decisions.
• Excellent communication, influence, and executive presentation skills.
• Demonstrated people leadership experience, including management, coaching, and development of scientific staff.

Required Skills

Clinical Development, Clinical Research Management, Clinical Sciences, Data Quality, Ethical Standards, High Performance Team Building, Immunology, Matrix Leadership, Matrix Management, Medical Monitoring, New Technology Integration, People Leadership, Pharmaceutical Industry, Regulatory Compliance, Therapeutic Knowledge, Trial Design.

Preferred Skills

Data Interpretations, Next Generation Science Standards, Study Design.