Senior Director, Clinical Science, Pulmonary Hypertension and Cardiovascular, Hybrid

Key Responsibilities

• Provide strategic Clinical Science leadership across the disease area, including multiple studies, programs, and assets.
• Contribute to disease area strategy by providing Clinical Science input on development opportunities, scientific considerations, portfolio risks, and implications of emerging internal and external data.
• Partner with Section Heads, Asset Leads, Program Development Team Leads, and cross-functional leaders to support alignment of Clinical Science activities with broader program and disease area objectives.
• Apply expert knowledge of therapeutic focus, disease biology, treatment landscape, and clinically meaningful endpoints to inform study planning, data interpretation, and issue resolution.
• Lead efforts to standardize Clinical Science approaches across the disease area, including medical data review practices, data interpretation principles, and key deliverables.
• Promote consistency in how Clinical Science activities are conducted across studies and programs while allowing for program-specific needs.
• Advocate for implementation of innovative approaches, including visual analytics, centralized data review, AI-enabled workflows, and other technologies that improve quality and efficiency.
• Provide senior scientific guidance across assigned studies and programs to support high-quality and consistent Clinical Science input.
• Guide interpretation of clinical data across studies, cohorts, and assets to support broader understanding of trends, opportunities, risks, and program implications.
• Contribute scientific perspective to protocol development, protocol amendments, study design considerations, endpoint selection, eligibility criteria, biomarker strategy discussions, and other development planning activities.
• Contribute Clinical Science perspective to portfolio discussions, governance reviews, and senior leadership meetings within their disease area.
• Provide direct management for Directors, Principal Scientists, and Clinical Scientists, as appropriate.
• Support development of Clinical Science talent through coaching, mentoring, feedback, and creation of development opportunities.
• Partner closely with Clinical Operations, Regulatory Affairs, Biostatistics, Data Management, Drug Safety and Pharmacovigilance, Translational Medicine, Medical Affairs, and other key partner functions.
• Ensure Clinical Science activities are conducted in accordance with applicable regulatory requirements, company policies, and established procedures.

Qualifications, Skills & Experience

Core Leadership Skills: Sets clear direction aligned with business and organizational priorities. Demonstrates strong scientific and strategic judgment in complex and ambiguous situations. Builds strong, collaborative relationships across functions and levels. Develops people through coaching, feedback, and support for growth. Creates an inclusive environment where perspectives are valued. Drives accountability and high standards for quality and performance. Communicates clearly and effectively with team members, cross-functional partners, and senior leaders. Leads through influence in a matrix environment and helps teams align around shared goals. Encourages continuous improvement, learning, and thoughtful challenge. Balances enterprise thinking with practical decision-making and timely action.

Education: Advanced scientific or healthcare degree required (e.g., PhD, PharmD), or equivalent, and 8+ years of pharmaceutical, clinical drug development, and/or medical field experience preferred -OR- Master’s degree, preferably in life sciences, and 12+ years of pharmaceutical, clinical drug development, and/or medical field experience -OR- Bachelor’s degree, preferably in life sciences, and 15+ years of pharmaceutical, clinical drug development, and/or medical field experience.

Experience: Significant experience in Clinical Development, Clinical Science, clinical drug development, or a related function within the pharmaceutical or biotechnology industry. Demonstrated experience providing Clinical Science leadership across multiple studies, programs, or assets. Deep therapeutic area expertise, including strong understanding of disease biology, current and emerging treatment landscape, clinically relevant endpoints, and key scientific considerations affecting development. Strong understanding of clinical trial design, clinical development strategy, clinical data review, and interpretation of oncology data. Experience contributing to disease area strategy, portfolio discussions, or cross-program planning. Experience contributing to regulatory submissions, safety reviews, or health authority interactions. Experience working effectively in cross-functional teams within a matrix environment. Demonstrated ability to integrate information across studies and programs to support scientific and business decisions. Excellent communication, influence, and executive presentation skills. Demonstrated people leadership experience, including management, coaching, and development of scientific staff.