Senior Director, Clinical Translational Scientist
Repertoire Immune Medicines
Summary
Repertoire Immune Medicines is seeking a seasoned, immunology-focused pharmacology leader to shape and advance a portfolio of T cell–targeted therapies in oncology and autoimmune disease. Reporting to the SVP of Integrated Therapeutic Engineering and Development, this individual will play a leading role in development-stage research strategy and execution, driving programs from discovery through IND-enabling studies.
Job description
Responsibilities
- Lead development and execution of integrated translational medicine strategies across clinical development programs.
- Develop and continually refine biomarker and clinical pharmacology plans to support target engagement, proof-of-mechanism, proof-of-biology, dose optimization, and patient selection.
- Translate emerging biological, pharmacological, and clinical data into actionable development recommendations.
- Identify and prioritize translational milestones to inform key portfolio decisions and stage-gate transitions.
- Define biomarker strategies spanning exploratory, pharmacodynamic, predictive, prognostic, and diagnostic biomarkers.
- Partner with bioanalytical and laboratory teams to develop, validate, and implement clinical biomarker assays.
- Lead interpretation of biomarker, PK/PD, and clinical datasets to generate insights regarding mechanism of action, treatment response, and resistance pathways.
- Support implementation of innovative technologies and emerging translational approaches.
- Contribute to study design, protocol development, endpoint selection, statistical analysis planning, and clinical study execution.
- Build productive relationships with internal stakeholders, external partners, CROs, academic investigators, key opinion leaders, and laboratory vendors.
- Contribute translational components to regulatory submissions including INDs, briefing documents, and marketing applications.
- Support interactions with health authorities related to biomarkers, companion diagnostics, and translational strategy.
- Maintain awareness of emerging scientific advances and competitive developments within oncology, immunology, and related therapeutic areas.
- Foster a collaborative, patient-focused, and scientifically rigorous culture.
- Contribute to departmental strategy, capability building, and organizational development.
Qualifications and Experience
- PhD, MD, or MD/PhD in Immunology, or related discipline.
- Advanced clinical development and translational medicine expertise strongly preferred.
- Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs.
- Proven ability to integrate scientific, biomarker, and clinical data to deepen the understanding of patient populations and drug mechanism of action in patients.
- Experience leading and influencing cross-functional teams across Research, Clinical Development, and Regulatory Affairs.
- Demonstrated success supporting programs from early clinical development through proof-of-concept and late-stage studies in oncology.
Requirements
- PhD, MD, or MD/PhD in Immunology, or related discipline
- Advanced clinical development and translational medicine expertise strongly preferred
- Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs
- Proven ability to integrate scientific, biomarker, and clinical data to deepen understanding of patient populations and drug mechanism of action
- Experience leading and influencing cross-functional teams across Research, Clinical Development, and Regulatory Affairs
- Demonstrated success supporting programs from early clinical development through proof-of-concept and late-stage studies in oncology
Benefits
- Medical, Dental & Vision
- Life Insurance
- Flexible Time Off
- 401(k) Retirement Plan
- Short-term Incentives
- Long-term Incentives
Company overview
Repertoire Immune Medicines is a biotechnology company pioneering the development of novel immune-based therapeutics through its proprietary DECODE platform. The company focuses on discovering and developing T-cell receptor (TCR)-based medicines for cancer and autoimmune diseases. By leveraging advanced computational biology and high-throughput sequencing technologies, Repertoire aims to map the complete repertoire of T-cell receptors and identify disease-specific targets. The company's innovative approach combines immunology expertise with machine learning to decode the immune system's language and develop precision immunotherapies. Based in Cambridge, Massachusetts, Repertoire Immune Medicines represents a cutting-edge convergence of immunology, genomics, and computational science to create transformative treatments for patients with serious diseases.