Senior Director, Commercial Forecasting & Artificial Intelligence
Immatics
Summary
We are seeking a Senior Director, Commercial Forecasting & AI combined role. Approximately half of the position is owning demand, revenue and patient-flow forecasting across Immatics’ portfolio — from early pipeline opportunity assessment through launch readiness and in-line performance. The other half is serving as the Commercial organization’s in-house AI expert: identifying, building and scaling AI and generative-AI capabilities that make a small commercial team perform like a much larger one.
Job description
In this role you will:
- Develop Commercial AI roadmap — Serve as the Commercial team’s resident AI expert across the full commercial organization: partner with Marketing, Market Access, Medical Affairs and Field Operations to identify, prioritize and sequence high-value AI and generative-AI use cases — analytics and forecasting, market research synthesis, competitive intelligence, field enablement, content development and promotional review preparation, account and KOL intelligence, payer and policy monitoring, and CRM data quality — with a clear view of business impact, effort and sequencing.
- Build the operating systems — Design, build and own AI-powered systems that become how Commercial runs day to day — not one-off pilots. Re-engineer the analytics workflow end to end so recurring work runs itself: automated ingestion and QC of claims, specialty distributor, CRM and third-party data; reconciliation and exception flagging; forecast and dashboard refreshes; self-service analytics layers; recurring report and insight generation; and agentic workflows that take manual assembly off the critical path — shifting the team’s time from producing numbers to interpreting them.
- Build vs. buy and vendors — Evaluate AI platforms and vendors, run structured pilots against defined success criteria, and make defensible build-versus-buy recommendations.
Requirements
- Bachelor’s or equivalent years of experience
- 15+ years in Life sciences consultancy, biotech, pharma or related
- 7 Years of Forecasting, Commercial Analytics or market insights
- Demonstrated expertise building patient-based and epidemiology-driven forecast models from the ground up for both pre-launch and in-line assets
- Deep working knowledge of pharma/biotech data sources and their strengths and limitations — e.g. IQVIA, Symphony Health, Komodo, Definitive Healthcare, specialty distributor and 867/852 data, SEER and other epidemiology sources, clinical registries and syndicated market research
- Demonstrated, hands-on experience applying AI and large language models to real commercial problems in a regulated life sciences environment — including practical fluency with LLM platforms, prompt engineering, retrieval-augmented generation and agentic workflows, and a clear-eyed view of where AI does and does not work
- Working understanding of the compliance and privacy constraints on AI in life sciences (PHI/HIPAA, GDPR, promotional review, data licensing terms, emerging AI regulation)
- Advanced Excel modeling plus working proficiency in Python, SQL and a visualization tool (Power BI/Tableau)
- Experience across the launch lifecycle in oncology, cell and gene therapy, rare disease or another specialty/limited-distribution setting
- Proven ability to operate independently in a lean, fast-moving environment, and to translate complex quantitative and technical work into decision-ready recommendations for senior stakeholders
- Direct experience forecasting an autologous CAR-T, TCR-T or other engineered cell therapy asset, including site activation and manufacturing-constrained demand models
- Track record of standing up a forecasting or commercial AI capability at a pre-commercial or newly commercial company
- Exposure to global forecasting and to market access/pricing analytics in specialty oncology
Benefits
- Health Insurance
- Dental Insurance
- Vision Insurance
- 4 weeks vacation
- 12 paid holidays
- 7 days sick time
- Life Insurance
- Short-term Disability
- Long-term Disability
- 401(k) Matching
- Parental Leave
- Accident Insurance
- Hospital Indemnity Insurance
- Critical Illness Insurance
- Identity Theft Protection
- Pet Insurance
Company overview
Immatics is a clinical-stage biotechnology company and the global leader in precision targeting of PRAME (Preferentially Expressed Antigen in Melanoma), a cancer target expressed in more than 50 different cancer types. Founded in 2000 as a spin-off from the University of Tübingen's Department of Immunology, the company has grown into a publicly traded entity (NASDAQ: IMTX) with operations in Germany and the United States. Immatics specializes in developing T-cell redirecting immunotherapies, including TCR T-cell therapies and TCR bispecifics, for the treatment of solid tumors. The company's proprietary XPRESIDENT™ technology platform enables the identification of tumor-associated peptides (TUMAPs) with unprecedented sensitivity, allowing for the development of highly specific cancer immunotherapies. With a robust clinical pipeline focused on PRAME-targeting therapies, Immatics is advancing multiple programs including IMA203 (anzutresgene autoleucel) for PRAME-positive solid tumors, IMA402 PRAME bispecific, and IMA401 MAGEA4/8 bispecific. The company's innovative approach combines mass spectrometry, genomics, biochemistry, and immunology to create novel cancer treatments that address significant unmet medical needs in oncology.