Senior Director, Information Technology

The Senior Director, IT is responsible for leading the global IT organization at PacBio, encompassing teams that support enterprise, financial, manufacturing, and R&D information systems. This is a highly visible, cross-functional leadership role that partners closely with executive leadership and stakeholders across the company to enable business strategy, operational excellence, and innovation through secure, scalable, and compliant technology solutions.

Responsibilities

• Lead, develop, and scale a high-performing IT organization, including managers and senior technical leaders.
• Foster a culture of accountability, service excellence, security awareness, and continuous improvement.
• Define and execute a multi-year IT strategy and technology roadmap aligned with PacBio's business objectives.
• Partner closely with Finance, Manufacturing, R&D, Quality, Legal, and Commercial teams to support business needs and continually improve operational efficiency.
• Own PacBio's cybersecurity strategy, posture, and operations, including prevention, detection, response, and recovery.
• Ensure compliance with ISO 27001, SOX, and other applicable regulatory and audit requirements, including leading, coordinating, and interfacing directly with internal and external SOX auditors.
• Lead IT risk management, security governance, incident response planning, and third-party risk management.
• Establish and maintain security policies, standards, and controls across infrastructure, applications, and data.
• Partner with internal and external auditors to support audits and remediation activities.
• Ensure IT systems supporting regulated processes comply with validation and quality requirements (e.g., GxP).
• Own IT governance frameworks, including enterprise systems development, change management, access controls, and data governance.
• Maintain audit readiness and documentation across systems and processes.
• Oversee enterprise architecture, application portfolio management, and system lifecycle planning.
• Lead the operation and evolution of hybrid infrastructure, including on-premises and cloud environments.
• Support high-performance computing (HPC) and large-scale storage platforms for R&D and data-intensive workloads.
• Drive reliability, scalability, and performance of mission-critical systems.
• Drive modernization initiatives, including cloud adoption, automation, and legacy system rationalization.
• Own the IT budget, forecasting, and cost optimization initiatives.
• Manage strategic vendor relationships, system integrators, and managed service providers.

Required Qualifications

• Bachelor's degree in Information Systems, Computer Science, Engineering, or a related field; advanced degree preferred.
• 12+ years of progressive IT experience, including significant leadership at the director or senior director level.
• Experience in a public company, preferably within life sciences, biotechnology, or a regulated industry.
• Demonstrated experience with SOX compliance, remediation, and internal/external audits.
• Hands-on leadership experience with ISO 27001 security frameworks and certification efforts.
• Strong knowledge of system validation, enterprise architecture, application management, and IT governance.
• Proven experience managing hybrid IT environments, including cloud, on-premises infrastructure, HPC, and storage.
• Experience with and understanding of Jira Service Desk, SAP, Anaplan, Salesforce, PLM, and MES (Siemens Opcenter).
• Provide strategic oversight and guidance for PacBio's SAP ERP platform, ensuring alignment with business objectives, compliance requirements, and enterprise architecture standards.
• Excellent executive communication skills and ability to influence across functions.

Preferred Experience

• Experience taking mature organizations through ISO 27001 certification.
• Experience supporting manufacturing, laboratory, and R&D systems in regulated environments.
• Familiarity with data privacy regulations and global security standards.
• Track record of leading IT and security transformations at scale.
• Experience supporting SAP.
• Understanding of Quote to Cash processes in a Salesforce environment.
• Experience building and supporting data lakes.