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Senior Director, Tax

Guardant Health

Palo Alto, CAHybridPosted 40 days ago$232,220 - $375,650/year
Full TimeDirector & AboveCorporate FunctionsDiagnostics
Original posting ↗

Summary

Guardant Health is seeking a strategic and hands-on Senior Director, Tax to lead the Company's global tax function. As the most senior tax professional within the organization, this role will have overall responsibility for the Company's income tax accounting, compliance, reporting, planning, transfer pricing, indirect tax, tax controversy, and tax-related business initiatives. Reporting to the Senior Vice President, Chief Accounting Officer, the Senior Director, Tax will serve as a trusted advisor to executive leadership and key business partners across Finance, Legal, Treasury, Human Resources, FP&A, Procurement, and Operations.

Job description

Primary Responsibilities

Tax Accounting & Reporting

  • Lead quarterly and annual income tax accounting under ASC 740, including preparation and review of tax provisions, effective tax rate analysis, deferred tax calculations, uncertain tax positions, and related disclosures.
  • Ensure accurate tax reporting for SEC filings, financial statements, and management reporting.
  • Partner closely with Corporate Accounting and Financial Reporting teams during monthly, quarterly, and annual close cycles.
  • Review and improve tax-related controls and SOX compliance activities.

Global Tax Compliance

  • Oversee all federal, state, local, and international tax compliance activities.
  • Manage external tax service providers responsible for preparation and filing of tax returns.
  • Monitor legislative and regulatory developments and assess impacts to the Company.
  • Ensure timely completion of tax filings, estimated payments, extensions, and reporting requirements.

Tax Planning & Strategy

  • Develop and execute tax planning initiatives aligned with business objectives.
  • Identify and implement opportunities to optimize the Company's effective tax rate, cash tax position, and utilization of tax attributes.
  • Provide tax guidance and recommendations to executive leadership.
  • Lead tax analysis and execution support for acquisitions, restructurings, financing arrangements, international expansion, and other strategic transactions.
  • Support tax due diligence, integration planning, and structuring for acquisitions, investments, licensing arrangements, and other strategic transactions.
  • Evaluate and develop strategies related to tax attributes, including net operating losses, tax credits, and ownership change considerations.
  • Navigate optimal utilization of net operating losses.
  • Periodic evaluation of valuation allowance on net deferred tax assets.

International Tax & Transfer Pricing

  • Oversee global tax structures and international tax compliance requirements.
  • Manage transfer pricing policies, documentation, and intercompany arrangements.
  • Partner with international finance teams to ensure tax-efficient operational structures.
  • Monitor emerging global tax legislation and regulatory developments, including international tax reform initiatives, and assess impacts to the Company.
  • Optimize global tax planning to achieve a balance between tax efficient structures and our ability to repatriate cash as needed, including regular evaluations of whether the company is permanently reinvested as applicable in international jurisdictions.

Indirect Tax

  • Oversee sales and use tax, VAT/GST, property tax, and other indirect tax obligations.
  • Manage nexus assessments and compliance processes.
  • Support implementation and enhancement of indirect tax automation solutions.
  • Optimize utilization of available R&D tax credits.

Tax Risk Management

  • Lead tax audits, inquiries, and examinations.
  • Manage relationships with tax authorities and external advisors.
  • Assess tax risks and develop mitigation strategies.
  • Maintain strong internal controls over tax processes.
  • Resolve tax audits, notices, examinations, and inquiries across domestic and international jurisdictions.

Business Partnership & Leadership

  • Serve as the Company's primary tax subject matter expert.
  • Provide guidance to Accounting, Treasury, Legal, HR, Procurement, and FP&A on tax matters.
  • Support strategic initiatives, system implementations, process improvements, and finance transformation efforts.
  • Manage external tax consultants and future internal tax team resources.
  • Build scalable tax processes, documentation, and governance frameworks.
  • Partner with FP&A on forecasting and modeling of effective tax rate, cash taxes, and tax-related business impacts.
  • Identify and implement opportunities to improve tax processes, controls, automation, and use of technology.
  • Evaluate staffing needs and build the tax organization as the company continues to scale.

Qualifications

  • Bachelor's degree in Accounting, Finance, Taxation, or related field; CPA required.
  • Master's in Taxation (MST) or other advanced tax credential preferred.
  • 15+ years of progressive tax experience, including a combination of Big Four/public accounting and corporate tax leadership experience within a publicly traded multinational organization.
  • Strong technical expertise in ASC 740, U.S. federal and state taxation, international taxation, transfer pricing, and tax planning.
  • Experience serving in a leadership role responsible for tax accounting, reporting, and compliance within a publicly traded multinational company.
  • Demonstrated experience managing global tax compliance, tax provision, audits, and tax controversy matters.
  • Experience supporting multinational operations and navigating complex international tax regulations and emerging global tax reform initiatives, including transition to positive tax income and utilization of NOLs.
  • Proven ability to develop and implement tax strategies that support business growth while minimizing tax risk.
  • Demonstrated ability to communicate complex tax matters to executive leadership, auditors, and non-tax stakeholders.
  • Experience managing external tax advisors, consultants, and service providers.
  • Strong knowledge of internal controls, SOX compliance, and tax governance frameworks.
  • Experience with ERP and tax technology platforms such as Oracle Fusion, Vertex, or similar systems.
  • Strong business acumen with the ability to partner effectively across Finance, Legal, Treasury, HR, FP&A, Procurement, and executive leadership teams.
  • Demonstrated leadership capabilities, including the ability to influence stakeholders, lead cross-functional initiatives, and build scalable processes in a growing organization.
  • Experience in life sciences, healthcare, biotechnology, diagnostics, medical device, or other highly regulated industries is preferred.

AI & Digital Fluency

Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.

Requirements

  • Bachelor's degree in Accounting, Finance, Taxation, or related field
  • CPA required
  • Master's in Taxation (MST) or other advanced tax credential preferred
  • 15+ years of progressive tax experience
  • Combination of Big Four/public accounting and corporate tax leadership experience within a publicly traded multinational organization
  • Strong technical expertise in ASC 740
  • Strong technical expertise in U.S. federal and state taxation
  • Strong technical expertise in international taxation
  • Strong technical expertise in transfer pricing
  • Strong technical expertise in tax planning
  • Experience serving in a leadership role responsible for tax accounting, reporting, and compliance within a publicly traded multinational company
  • Demonstrated experience managing global tax compliance, tax provision, audits, and tax controversy matters
  • Experience supporting multinational operations and navigating complex international tax regulations and emerging global tax reform initiatives
  • Proven ability to develop and implement tax strategies that support business growth while minimizing tax risk
  • Demonstrated ability to communicate complex tax matters to executive leadership, auditors, and non-tax stakeholders
  • Experience managing external tax advisors, consultants, and service providers
  • Strong knowledge of internal controls, SOX compliance, and tax governance frameworks
  • Experience with ERP and tax technology platforms such as Oracle Fusion, Vertex, or similar systems
  • Strong business acumen with the ability to partner effectively across Finance, Legal, Treasury, HR, FP&A, Procurement, and executive leadership teams
  • Demonstrated leadership capabilities, including the ability to influence stakeholders, lead cross-functional initiatives, and build scalable processes in a growing organization
  • Experience in life sciences, healthcare, biotechnology, diagnostics, medical device, or other highly regulated industries is preferred

Benefits

  • Hybrid Work Model
  • Medical, Dental & Vision
  • 401(k) Matching
  • Paid Time Off
  • Bonus
  • Equity

Company overview

Guardant Health, Inc. is a leading precision oncology company headquartered in Palo Alto, California, focused on transforming cancer care through advanced blood and tissue testing technologies. Founded in 2012 by Helmy Eltoukhy and AmirAli Talasaz, who serve as co-CEOs, the company specializes in liquid biopsy tests that detect cancer from circulating tumor DNA in blood samples. Guardant Health's flagship product, Guardant360, was the first comprehensive liquid biopsy test approved by the FDA for tumor mutation profiling and companion diagnostics in non-small cell lung cancer. The company has expanded its portfolio to include Guardant Reveal for residual disease monitoring, Guardant360 TissueNext tissue testing, and Shield, the first FDA-approved blood test for colorectal cancer screening. Guardant Health operates globally with approximately 1,999 employees and generates revenue from precision oncology testing services for clinical and biopharmaceutical customers, as well as development services and technology licensing. The company's innovative approach enables earlier cancer detection, treatment selection, and monitoring, helping to improve patient outcomes across all stages of cancer care.

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