Senior Manager, Biophysics, Higher-Order Structure & Separations

Purpose

We are seeking an experienced scientific leader to build and lead our Biophysics, Higher-Order Structure & Separations team within Cell Engineering and Analytical Sciences (CEAS). This is a unique opportunity to create and advance a scientific capability that directly impacts how biologic drug candidates progress from late Discovery through Cell Line Development and into process and product development.

Responsibilities

• Define and execute the scientific strategy for biophysics, higher-order structure characterization, and separation sciences within CEAS.
• Build a world-class capability focused on understanding the relationship between molecular properties and development outcomes.
• Serve as a scientific leader and trusted partner across Discovery, Cell Line Development, Process Development, and Analytical Sciences organizations.
• Evaluate and implement emerging technologies that enhance molecular understanding and accelerate decision-making.
• Partner closely with Cell Line Development teams to understand how molecular characteristics influence expression, clone selection, product quality, and overall development performance.
• Apply biophysical characterization approaches to identify molecule-specific liabilities and opportunities early in development.
• Generate mechanistic insights that inform risk mitigation strategies and improve likelihood of successful scale-up and manufacturing.
• Help establish characterization frameworks that connect molecular structure and behavior with development and manufacturing outcomes.
• Support scientific investigations that explain differences in development performance across multiple candidate molecules advancing within the same program.
• Build and expand capabilities for higher-order structure characterization, conformational analysis, protein stability assessment, and aggregation investigations.
• Develop orthogonal analytical approaches that provide complementary information to structural and analytical mass spectrometry.
• Apply advanced spectroscopic, calorimetric, hydrodynamic, and separation-based techniques to understand molecular behavior.
• Establish deep scientific understanding of structure-function relationships and their impact on development and manufacturing.
• Advance protein separations and biophysical characterization capabilities supporting a broad range of biologic modalities.
• Characterize molecular heterogeneity, aggregation, fragmentation, charge variants, and other critical quality attributes.
• Integrate data across biophysics, separation sciences, and mass spectrometry to provide comprehensive assessments of molecule behavior and risk.
• Deliver high-quality scientific recommendations that support project teams and portfolio decisions.
• Recruit, mentor, and develop exceptional scientists.
• Create a culture centered on scientific rigor, curiosity, innovation, collaboration, and operational excellence.
• Develop organizational capabilities aligned with future portfolio and technology needs.
• Foster technical growth and establish the team as a recognized center of excellence in molecular characterization.