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Senior Principal Product Leader

Roche

South San Francisco, CAHybridPosted 1 day ago$170,200 - $316,000/year
Full TimeDirector & AboveTech & Data (Health IT)Pharmaceutical
Original posting ↗

Summary

As the Senior Principal Product Leader for AI & Lab Automation within the Data and Digital Catalysts (DDC) department of the Computational Sciences Center of Excellence (CS CoE), you will drive the global product strategy that bridges artificial intelligence, intelligent robotics, and scientific workflows across gRED and pRED. In this role, you will shape the digital backbone of our research laboratories today while architecting autonomous, closed-loop labs for tomorrow.

Job description

The Opportunity

As the Senior Principal Product Leader for AI & Lab Automation within the Data and Digital Catalysts (DDC) department of the Computational Sciences Center of Excellence (CS CoE), you will drive the global product strategy that bridges artificial intelligence, intelligent robotics, and scientific workflows across gRED and pRED. In this role, you will shape the digital backbone of our research laboratories today while architecting autonomous, closed-loop labs for tomorrow.

  • Own the multi-year product vision, strategy, and roadmap for AI-orchestrated laboratory workflows and automation globally
  • Identify high-value opportunities where AI, intelligent automation, optimization, and agentic capabilities can improve experiment planning, laboratory execution, scientific throughput, and researcher experience.
  • Partner closely with scientists and laboratory teams to understand existing workflows and determine where automation, AI, or workflow redesign can remove bottlenecks and improve experimental outcomes.
  • Guide emerging capabilities—including experiment planning, intelligent scheduling, agentic execution, and anomaly detection—from prototype to production-scale scientific adoption.
  • Lead multidisciplinary global teams spanning product, scientific SMEs, AI/ML, software and data engineering, automation engineering, UX, laboratory operations, security, quality, and external vendors.
  • Establish quantifiable OKRs and product telemetry to track improvements in experimental cycle times, scientific throughput, reproducibility, and data quality.
  • Drive human-in-the-loop operational frameworks and safety guardrails, balancing autonomous execution with scientific oversight and validated laboratory protocols.

Who you are

  • You bring 12+ years of experience in product leadership, scientific technology, laboratory automation, or research informatics with deep accountability for complex scientific platforms.
  • You demonstrate a proven track record of conceptualizing, deploying, and scaling AI/ML-driven products, optimization engines, or autonomous systems in physical or laboratory execution environments.
  • You hold a deep domain understanding of wet lab workflows, instrument robotics, integrated work cells, scheduling systems, and scientific data architectures (metadata, provenance, ontologies, and FAIR data principles).
  • You possess proven experience leading cross-functional matrixed initiatives and aligning multidisciplinary teams (software engineering, wet lab scientists, AI specialists, and operations).
  • You exhibit exceptional executive communication and storytelling skills, with the ability to translate complex AI and physical automation concepts into actionable strategy for diverse scientific and technical audiences.

Preferred

  • Advanced degree (Master’s or Ph.D.) in Life Sciences, Bioengineering, Robotics, Computer Science, AI/ML, or an adjacent quantitative discipline.
  • Hands-on technical familiarity with high-throughput laboratory automation ecosystems (e.g., automated liquid handlers, plate readers, robotic arms, scheduling software).
  • Prior domain exposure to automated experimentation within high-throughput screening, genomics, protein sciences, bioanalytics, or synthetic chemistry.

Location

  • This role is based in South San Francisco and offers a hybrid schedule working 3 day per week on campus
  • No relocation benefits are available for this posting

Requirements

  • 12+ years of experience in product leadership, scientific technology, laboratory automation, or research informatics
  • Proven track record of conceptualizing, deploying, and scaling AI/ML-driven products, optimization engines, or autonomous systems
  • Deep domain understanding of wet lab workflows, instrument robotics, integrated work cells, scheduling systems, and scientific data architectures
  • Proven experience leading cross-functional matrixed initiatives and aligning multidisciplinary teams
  • Exceptional executive communication and storytelling skills
  • Advanced degree (Master’s or Ph.D.) in Life Sciences, Bioengineering, Robotics, Computer Science, AI/ML, or adjacent quantitative discipline (preferred)
  • Hands-on technical familiarity with high-throughput laboratory automation ecosystems (preferred)
  • Prior domain exposure to automated experimentation within high-throughput screening, genomics, protein sciences, bioanalytics, or synthetic chemistry (preferred)

Benefits

  • Annual bonus
  • Health insurance

Company overview

Roche is a Swiss multinational healthcare company and a global pioneer in pharmaceuticals and diagnostics, founded in 1896 and headquartered in Basel, Switzerland. As the world's largest biotech company and the fifth-largest pharmaceutical company by revenue, Roche operates through two primary divisions: Pharmaceuticals and Diagnostics. The company is renowned for its leadership in personalized healthcare, combining strengths in both drug development and diagnostic testing to deliver tailored treatments for patients. Roche maintains a strong focus on oncology, immunology, infectious diseases, ophthalmology, and central nervous system disorders, with a portfolio that includes over 30 medicines on the World Health Organization's Model Lists of Essential Medicines. The company owns significant subsidiaries including Genentech, Chugai Pharmaceuticals, Ventana Medical Systems, and Foundation Medicine. With approximately 103,000 employees worldwide and operations in over 100 countries, Roche has established itself as a leader in cancer treatments globally while maintaining a robust pipeline of innovative therapies and diagnostic solutions. The company's commitment to sustainability has been recognized through ten consecutive years as Group Leader in the Dow Jones Sustainability Indices within the Pharmaceuticals, Biotechnology & Life Sciences Industry.

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