Senior Principal Scientist, Skin Biology and Inflammation

Key Responsibilities

• Provide scientific leadership for discovery programs, technology platforms, or strategic initiatives focused on skin biology and inflammatory disease.
• Define compelling, human-biology-driven hypotheses and translate them into integrated experimental and computational strategies for target identification, validation, patient segmentation, and differentiated therapeutic approaches.
• Bring deep expertise in keratinocyte biology, stem cells, stromal and fibroblast biology, epithelial-neuro-immune interactions, skin inflammation, tissue remodeling, barrier biology, and/or diseases of the skin.
• Design, direct, and interpret complex studies using relevant human tissues and advanced preclinical systems, which may include primary cells, organotypic cultures, co-culture systems, spatial and single-cell approaches, perturbational biology, and disease-relevant in vivo models.
• Continuously apply AI-enabled, computational, agentic, and data-science approaches to synthesize evidence, generate mechanistic insights, prioritize experiments, and improve the speed and quality of scientific decision-making.
• Partner with computational scientists, engineers, automation experts, translational scientists, human geneticists, clinicians, and project teams to develop integrated datasets and predictive biological models.
• Identify, evaluate, and implement emerging technologies that materially improve how skin biology is studied, including next-generation tissue models, imaging, multi-omics, high-content phenotyping, functional genomics, and scalable experimental platforms.
• Guide program strategy, milestone definition, experimental prioritization, risk assessment, and resolution of complex scientific issues.
• Be accountable for scientific quality and delivery against longer-term objectives.
• Influence project, departmental, and broader functional strategy by recognizing external scientific and technology trends and translating them into actionable opportunities.
• Lead and contribute to cross-functional teams, creating clarity in an evolving environment and connecting expertise across the organization to deliver results.
• Coach and provide scientific and technical guidance to colleagues across the function, while fostering an inclusive, connected, curious, and high-performing research culture.
• Communicate scientific strategy, evidence, uncertainty, and recommendations effectively to project teams, senior leaders, governance bodies, and external scientific audiences.
• Build external scientific eminence through influential collaborations, conference participation, publications, patents, and other reviewed scientific or technical outputs.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of relevant experience OR Master’s degree and 6 years of relevant experience OR Bachelor’s degree and 8 years of relevant experience

Preferred Qualifications

• Deep expertise in keratinocyte biology, stromal or fibroblast biology, skin inflammation, epithelial-immune crosstalk, wound repair, tissue remodeling, and/or inflammatory diseases of the skin.
• Strong record of applying human tissues, disease-relevant cellular systems, organotypic models, spatial biology, single-cell methods, imaging, omics, functional genomics, or perturbational approaches to define mechanisms.
• Demonstrated experience using AI-enabled tools, machine learning, computational biology, agentic research workflows, advanced analytics, or data integration to generate and test biological hypotheses.
• Ability to identify where technology can create a step change in biological understanding, then build partnerships and workflows that convert promising concepts into robust capabilities.
• Experience advancing drug discovery programs and understanding how target biology connects to modality, biomarkers, translational strategy, clinical differentiation, and portfolio value.
• Evidence of scientific influence beyond an immediate team, such as cross-functional leadership, external collaborations, invited presentations, senior authorship, patents, or other recognized contributions.
• Excellent written and verbal communication skills, including the ability to frame complex science, uncertainty, and recommendations for technical and senior leadership audiences.
• Demonstrated excellence in project leadership and the ability to balance scientific rigor, strategic focus, urgency, adaptability, and operational execution.
• Commitment to coaching others, sharing knowledge, and building a connected, inclusive, and inspiring environment in which colleagues can thrive.