Senior Research Associate, In vivo Pharmacology

Purpose & Scope

The In Vivo Senior Research Associate is responsible for executing preclinical in vivo studies and generating reliable pharmacology data to support research project decisions. This position provides specialized in vivo expertise that is essential for the successful evaluation and advancement of therapeutic candidates.

Role and Responsibilities

• Execute and support preclinical in vivo oncology and immunotherapy studies using mouse tumor models, including xenograft and syngeneic systems.
• Perform routine animal handling, restraint, health monitoring, and study-related procedures in compliance with approved protocols and animal welfare regulations.
• Conduct in vivo procedures including intravenous (IV), intraperitoneal (IP), oral gavage, subcutaneous, and other administration routes as required.
• Perform surgical procedures and tumor implantation to establish and maintain in vivo cancer models.
• Randomize animals into study groups and monitor clinical observations, body weight, and study endpoints.
• Collect biological samples, including blood, tissues, and tumors, and ensure accurate documentation of all study activities in accordance with company SOPs and applicable regulations.
• Apply hands-on expertise in cell culture, ex vivo flow cytometry, and data analysis to support translational and pharmacology studies.
• Ensure full compliance with IACUC, institutional policies, and regulatory requirements governing animal care and use.
• Collaborate effectively with scientists and cross-functional research teams to support preclinical oncology and pharmacology programs.
• Contribute to the generation of high-quality, reliable scientific data that supports project decision-making and advancement of therapeutic candidates.

Qualifications

Required Qualifications

• BS degree in Biology, Pharmacology, Animal Science, or a related scientific discipline with 3yrs of hands-on laboratory experience supporting preclinical in vivo studies or MS degree with minimum 1yr hands-on laboratory experience in pharmaceutical or biotech industry.
• Demonstrated experience with rodent handling techniques, including tumor implantation, animal randomization, and dosing procedures (IV, IP).
• Experience performing in vivo oncology and/or immunology studies, including tumor model establishment and monitoring.
• Hands-on experience with immuno-flow cytometry, ex vivo tissue processing, tissue culture, and related biological sample analyses.
• Knowledge of animal welfare regulations and experience working in compliance with IACUC, institutional, and regulatory requirements.

Preferred Qualifications

• Experience with additional rodent dosing techniques, including IV, oral gavage (PO), subcutaneous (SC), and other specialized administration routes.
• Proven ability to independently analyze and interpret ex vivo flow cytometry data using FlowJo to support tumor immunology and mechanism-of-action studies.
• Experience supporting oncology, immunology, or pharmacology programs in a drug discovery or translational research environment.
• Familiarity with electronic laboratory and study management platforms such as Benchling, Studylog, GraphPad Prism, and FlowJo.
• Experience with advanced tissue processing, immune profiling, and biomarker analyses.
• Experience working in GLP-regulated or SOP-driven research environments.
• Experience contributing to protocol development, process optimization, or implementation of best practices in in vivo research.