Summary

We are seeking a highly motivated Senior Research Associate to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role will support our in vivo CAR-T platform, contributing to preclinical development from construct screening through animal model efficacy studies. You will work with the team to plan, execute, and troubleshoot experimental assays and laboratory methods, including cell-based functional and cytotoxicity assays, multi-color flow cytometry, ELISA and PCR-based assays, and viral vector packaging and titration.

Job description

Role Overview

We are seeking a highly motivated Senior Research Associate to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role will support our in vivo CAR-T platform, contributing to preclinical development from construct screening through animal model efficacy studies. You will work with the team to plan, execute, and troubleshoot experimental assays and laboratory methods, including cell-based functional and cytotoxicity assays, multi-color flow cytometry, ELISA and PCR-based assays, and viral vector packaging and titration.

Key Responsibilities

Package and titer lentivirus
Design and execute in vitro functional assays for safety and potency
Perform construct screening for CAR design
Handle and engineer human and murine T cells
Engineer and maintain various cancer cell lines for model development
Analyze and interpret data, troubleshoot, and maintain detailed experimental records

Requirements

BS or MS in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field
Primary human T cell isolation, activation, lentiviral transduction, and expansion required
Familiarity with Incucyte, MSD, LDH release assay
Multicolor flow cytometry: panel design, data acquisition (e.g., Attune, Novocyte, Cytek Aurora), and analysis (FlowJo)
Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot
High-throughput screening of drug candidates in the biotech setting
Experience in cell-based assay development and troubleshooting
Experience working with multiple immune cell types (T cell, B cell, myeloid) is a plus
Knowledge in specific tumor disease area

Requirements

BS or MS in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field
Primary human T cell isolation, activation, lentiviral transduction, and expansion
Familiarity with Incucyte, MSD, LDH release assay
Multicolor flow cytometry: panel design, data acquisition, and analysis (FlowJo)
Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot
High-throughput screening of drug candidates in the biotech setting
Experience in cell-based assay development and troubleshooting
Experience working with multiple immune cell types (T cell, B cell, myeloid) is a plus
Knowledge in specific tumor disease area
Authorized to work in the United States

Company overview

Legend Biotech is a global, commercial-stage biotechnology company specializing in the development and manufacturing of advanced cell therapies. Headquartered in Somerset, New Jersey, the company was founded in 2014 and has grown to become a leader in the cell therapy space with over 2,600 employees worldwide. Legend Biotech focuses on innovative cellular immunotherapy platforms, including autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies, natural killer (NK) cell-based immunotherapies, and non-gene-editing universal CAR-T technologies. The company's flagship product, CARVYKTI® (ciltacabtagene autoleucel), developed in collaboration with Johnson & Johnson, is a BCMA-directed CAR-T therapy approved for the treatment of relapsed or refractory multiple myeloma. With a robust pipeline of 11 investigational therapies spanning multiple disease areas, Legend Biotech operates research and development facilities across the United States, Europe, and China, maintaining a strong commitment to transforming patient care through cutting-edge cellular therapies.