Senior Scientist, Discovery Science

Position Summary

We are seeking a motivated and highly collaborative Senior Scientist to join our Discovery Biology team. The successful candidate will bring a deep understanding of biochemistry, assay development, and tissue sample processing, with a strong track record of collaborating with in-vivo pharmacologists / in-vivo biologists, NGS scientists, and bioinformatics teams. The role also involves management of contract research organizations (CROs).

Key Responsibilities

• Drive translational platform innovation aligned with FL125's core strategic goals, with a focus on biochemical assay development, analysis of oligonucleotides in complex mixtures, and tissue processing.
• Generate and develop enhanced oligonucleotides in different biological settings and against a broad set of drug targets.
• Support the design of in vivo experiments based on protocols developed in-vitro.
• Work in close collaboration with biochemists, in-vivo biologists, NGS scientists, and bioinformatics teams.
• Work closely with CROs conducting in-vitro / in-vivo experiments to identify new drug molecules.
• Generate rapid and accurate turnaround of high-quality experimental data to drive decision-making for platform and pipeline programs.
• Establish and refine workflows, SOPs, and documentation practices for experimental processes at scale.
• Clearly communicate experimental design, results, challenges, and next steps in internal meetings and with external collaborators.

Qualifications

• PhD in molecular biology, biochemistry, drug discovery, or a related field, with 3+ years of industry experience in discovery research. Postdoctoral experience may also be acceptable depending on research focus.
• Hands-on experience designing and interpreting complex in vitro and ex vivo experimental workflows, including sample processing and assay development.
• Good understanding of in vivo experiments for drug discovery and development in mouse models.
• Some familiarity with high-dimensional readouts such as NGS and proteomics.
• Hands-on experience with standard biochemical techniques and an ability to troubleshoot and optimize complex experimental workflows.
• Track record of working in multidisciplinary teams, including biochemists, in vivo biologists, and bioinformaticians.
• Motivated team-player and independent force-of-nature with strong organizational and written/verbal communication skills.

Preferred Qualifications

• Experience working with oligonucleotides.
• Experience designing and executing mouse model experiments.
• Experience working with contract research organizations (CROs).