Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development

Responsibilities

• Lead research efforts, design and execute in vitro studies (multi-color flow cytometry, ELISA, luciferase, ddPCR, etc.) and collaborate with in vivo pharmacology group for in vivo studies to advance lentiviral-based delivery platform development.
• Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships.
• Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development.
• Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment.
• Work independently with minimal supervision while maintaining a high level of productivity, efficiency, and scientific rigor.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
• Analyze and interpret multidisciplinary data to generate actionable conclusions, identify key risks, and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed.
• Mentor and support junior scientists within the team.

Qualifications

• BS, MS, or PhD in immunology, oncology, cell biology, molecular biology, biochemistry, or related field with typically 10+ (BS), 8+ (MS), or 0-3+ (PhD) years of experience.
• Expertise in mammalian primary cell and cell line culture (primary T cells, PBMCs, whole blood, suspension and adherent cell lines), multi-color flow cytometry (panel design, acquisition, and analysis), and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is highly preferred.
• Experience with lentiviral vector design, production, and analytical characterization (e.g., titering, copy number analysis, transduction efficiency assessment) is highly preferred.
• Experience in evaluating vector biodistribution, transduction specificity, or safety-related parameters is a plus.
• Experience in CAR-T cell therapy and/or in vivo targeted delivery is a plus.
• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.
• Detail-oriented with a passion for delivering high-quality results.