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Senior Scientist I, Molecular Virology

Generate Biomedicines

Somerville, MAOnsitePosted 1 day ago$125,000 - $175,000/year
Full TimeSenior LevelResearch & ScientistAI Biotech
Original posting ↗

Summary

We are seeking a Senior Scientist in Molecular Virology to design, execute, and oversee independent and team-based research projects focused on viral vector and RNA delivery platforms, including lentiviral systems and virus-like particles (VLPs). In this newly created role, you will connect early discovery research with translational development, advancing research from in vitro evaluation through in vivo validation to support clinical candidate selection.

Job description

The Role

We are seeking a Senior Scientist in Molecular Virology to design, execute, and oversee independent and team-based research projects focused on viral vector and RNA delivery platforms, including lentiviral systems and virus-like particles (VLPs). In this newly created role, you will connect early discovery research with translational development, advancing research from in vitro evaluation through in vivo validation to support clinical candidate selection.

You will combine hands-on experimental work with scientific project leadership, partnering with computational scientists and therapeutic experts to develop and evaluate delivery platforms, interpret complex data, and communicate findings. You will also provide scientific guidance to research associates and mentor junior scientists.

Here's how you will contribute

  • Lead molecular virology research. Independently design, execute, and oversee molecular virology and mammalian cell culture experiments, including construct design and characterization in vitro and in vivo.
  • Develop platforms and assays. Develop and optimize high-throughput screening assays and workflows using qPCR/ddPCR, flow cytometry, Western blotting, and next-generation sequencing.
  • Translate data into scientific decisions. Analyze and interpret complex datasets, evaluate findings, and recommend next steps that advance research projects toward clinical candidate selection.
  • Collaborate across disciplines. Partner with computational scientists and therapeutic experts to develop and evaluate viral vector and RNA delivery platforms. Apply agentic platforms and protein design tools in support of research activities.
  • Maintain rigorous scientific documentation. Maintain accurate, complete, and compliant laboratory records and prepare technical reports, peer-reviewed manuscripts, and scientific content supporting regulatory filings, as appropriate.
  • Guide and communicate the science. Provide day-to-day scientific oversight to research associates, mentor junior scientists, and present findings in internal and external project reviews.
  • Take ownership of research progress. Establish clear research goals, track progress, and communicate findings, challenges, and setbacks transparently. Seek cross-functional input and adapt approaches as evidence evolves.
  • Uphold biosafety and laboratory standards. Ensure research activities adhere to institutional biosafety and laboratory compliance requirements.

The Ideal Candidate will have

  • A Ph.D. in Virology, Molecular Biology, Microbiology, Biochemistry, or a closely related life science discipline
  • 4+ years of relevant postdoctoral training or industry research and development experience in biotechnology or pharmaceuticals, with demonstrated ability to independently design and advance molecular virology research.
  • Hands-on experience in mammalian cell culture, viral propagation, reverse genetics, cloning, site-directed mutagenesis, and recombinant vector design.
  • Experience with qPCR, ddPCR, ELISA, flow cytometry, Western blotting, and mammalian/microbial transfection methods.
  • Experience with next-generation sequencing library preparation, CRISPR screening, and basic sequence and data analysis tools.
  • Demonstrated experience applying agentic platforms and protein design tools.
  • Proficiency with electronic laboratory notebooks (ELN) and laboratory information management systems (LIMS).
  • Strong project management and problem-solving skills, clear written and verbal communication, and demonstrated ability to collaborate effectively across disciplines and present findings to senior leadership.

Nice to Have

Experience with lentiviral systems and animal models.

Requirements

  • Ph.D. in Virology, Molecular Biology, Microbiology, Biochemistry, or a closely related life science discipline
  • 4+ years of relevant postdoctoral training or industry R&D experience in biotechnology or pharmaceuticals
  • Hands-on experience in mammalian cell culture, viral propagation, reverse genetics, cloning, site-directed mutagenesis, and recombinant vector design
  • Experience with qPCR, ddPCR, ELISA, flow cytometry, Western blotting, and mammalian/microbial transfection methods
  • Experience with next-generation sequencing library preparation, CRISPR screening, and basic sequence and data analysis tools
  • Demonstrated experience applying agentic platforms and protein design tools
  • Proficiency with electronic laboratory notebooks (ELN) and laboratory information management systems (LIMS)
  • Strong project management and problem-solving skills
  • Clear written and verbal communication
  • Demonstrated ability to collaborate effectively across disciplines and present findings to senior leadership

Benefits

  • Annual Bonus
  • Equity Compensation
  • Competitive Benefits Package

Company overview

Generate Biomedicines is a pioneering therapeutics company operating at the intersection of machine learning, biological engineering, and medicine. The company is revolutionizing drug discovery through its proprietary Generative Biology™ platform, which enables the on-demand generation of novel protein-based medicines across multiple therapeutic modalities. By studying millions of proteins to understand nature's functional encoding rules, Generate Biomedicines can design and create breakthrough medicines with unprecedented speed and success rates. The company's platform represents a fundamental shift in therapeutic development, moving beyond traditional discovery methods to programmed generation of biologics including antibodies, peptides, enzymes, and stealth proteins. With advanced AI algorithms and automated experimentation systems, Generate Biomedicines is advancing a pipeline of innovative therapies, including GB-0895 for severe asthma which is progressing to Phase 3 studies. As a Flagship Pioneering company, Generate Biomedicines combines cutting-edge computational biology with deep biological expertise to address humanity's most challenging diseases.

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