Summary

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The company is pioneering a new class of therapeutics that target oncogenic RAS mutations, which are among the most common drivers of human cancers. Revolution Medicines employs a unique approach to drug discovery, leveraging deep insights into RAS biology to develop small molecule inhibitors that can address previously undruggable targets. Their pipeline includes multiple clinical-stage candidates designed to inhibit various RAS pathway mutations, with a particular focus on KRAS G12C and other RAS variants. The company's scientific platform combines structural biology, medicinal chemistry, and computational approaches to design highly selective inhibitors. Revolution Medicines aims to transform cancer treatment by developing therapies that can overcome resistance mechanisms and provide durable clinical benefits for patients with RAS-driven malignancies. Their research represents a significant advancement in the field of targeted cancer therapy, addressing one of the most challenging areas in oncology drug development.

Job description

The Opportunity

Lead day-to-day operations to provide analytical support for API process R&D and manufacturing, formulation development and drug product manufacturing, and participate in cross-functional project team meetings.
Contribute to analytical development strategy for multiple projects.
Demonstrate technical expertise on analytical technologies and act as a subject matter expert for Analytical Development function.
Select appropriate analytical techniques and coach and/or manage the contract lab counterparts to perform analytical method development/validation/transfer to support development and manufacturing of API and drug product.
Critically review data from contract partners (CDMOs and/or CTLs).
Manage stability testing programs assigned.
Prepare, review, and/or approve study protocols, study reports, and CMC regulatory submission documents.
Collaborate with cross functional teams including but not limited to Medicinal Chemistry, DMPK, Toxicology, QA, Pharmaceutical Development, Process R&D, Project Management and Regulatory to timely achieve project goals.

Required Experience, Skills and Education

Master's degree with 10+ years or PhD with 8+ years of relevant industrial experience in analytical development.
Extensive experience leading analytical activities independently in small molecule drug development.
Experience managing projects at CROs/CDMOs.
Work experience and knowledge of regulatory submission (IND, IMPD, and/or NDA).
Effective written and verbal communication skills and interpersonal skills.
Extensive knowledge and understanding of current ICH guidelines, GMP guidelines, and related industry practices.
Strong problem-solving skills with sound technically driven decision-making ability.
Excellent scientific and business communication skills (verbal, written and technical), strong interpersonal/collaboration skills and planning skills.
Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems.
Ability to multi-task and thrive in a fast-paced innovative environment.

Preferred Skills

PhD (minimum MS degree) in analytical chemistry, organic chemistry or related discipline.

Requirements

Master's degree with 10+ years or PhD with 8+ years of relevant industrial experience in analytical development
Extensive experience leading analytical activities independently in small molecule drug development
Experience managing projects at CROs/CDMOs
Work experience and knowledge of regulatory submission (IND, IMPD, and/or NDA)
Effective written and verbal communication skills and interpersonal skills
Extensive knowledge and understanding of current ICH guidelines, GMP guidelines, and related industry practices
Strong problem-solving skills with sound technically driven decision-making ability
Excellent scientific and business communication skills (verbal, written and technical), strong interpersonal/collaboration skills and planning skills
Ability to think critically and creatively and be able to work independently to determine appropriate resources for resolution of problems
Ability to multi-task and thrive in a fast-paced innovative environment
PhD (minimum MS degree) in analytical chemistry, organic chemistry or related discipline

Benefits

Competitive cash compensation
Equity awards
Health benefits
Learning and development opportunities

Company overview

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies for RAS-addicted cancers. The company is pioneering a new class of therapeutics that target oncogenic RAS mutations, which are among the most common drivers of human cancers. Revolution Medicines employs a unique approach to drug discovery, leveraging deep insights into RAS biology to develop small molecule inhibitors that can address previously undruggable targets. Their pipeline includes multiple clinical-stage candidates designed to inhibit various RAS pathway mutations, with a particular focus on KRAS G12C and other RAS variants. The company's scientific platform combines structural biology, medicinal chemistry, and computational approaches to design highly selective inhibitors. Revolution Medicines aims to transform cancer treatment by developing therapies that can overcome resistance mechanisms and provide durable clinical benefits for patients with RAS-driven malignancies. Their research represents a significant advancement in the field of targeted cancer therapy, addressing one of the most challenging areas in oncology drug development.