Senior Scientist, Mass Spectrometry
BeiGene
Summary
As a Senior Scientist at BeOne Institute, you will play an important role in advancing cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches for drug discovery. Working at the interface of biology, chemistry, and technology development, you will collaborate with multidisciplinary teams to address challenging scientific questions, develop new analytical capabilities, and generate insights that can inform future therapeutic opportunities.
Job description
Essential Functions of the Job
- Contribute creatively to Institute research by generating ideas, challenging assumptions, and advancing innovative scientific projects.
- Design and execute mass spectrometry-based studies to address biological questions, support emerging therapeutic modalities, and enable drug discovery research.
- Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and pathway biology.
- Evaluate and implement new mass spectrometry technologies, workflows, and applications to enhance scientific and technical capabilities.
- Operate, maintain, troubleshoot, and continuously improve mass spectrometry platforms to ensure robust analytical performance and high-quality data generation.
- Analyze, interpret, and communicate mass spectrometry data, translating analytical results into meaningful biological and drug discovery insights.
- Collaborate closely with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches and support multidisciplinary research efforts.
- Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.
Supervisory Responsibilities
- May be a contact for external CRO partners when needed
- May provide matrix or line-function leadership for project teams when needed
Computer Skills
- Proficiency with mass spectrometry data acquisition, processing, and analysis software
- Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets
- Experience with software and tools for MS-based screening and assay development
Required Qualifications
- Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. strongly preferred.
- Strong foundation in mass spectrometry, with hands-on experience operating, troubleshooting, and optimizing LC-MS instrumentation.
- Experience developing and implementing mass spectrometry-based analytical, screening, and/or proteomics workflows.
- Demonstrated ability to apply mass spectrometry approaches to address biological questions and support drug discovery research.
- Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
- Experience developing and optimizing sample preparation, chromatography, and mass spectrometry methods for biological applications.
- Strong data analysis and interpretation skills, with the ability to derive meaningful conclusions from complex mass spectrometry datasets.
- Ability to troubleshoot analytical challenges and contribute creative solutions to technical and scientific problems.
- Ability to collaborate effectively with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches.
- Strong written, verbal, and presentation skills, with the ability to communicate scientific findings to multidisciplinary teams.
- Ability to work on-site in San Carlos, CA.
Preferred Qualifications
- Experience with Orbitrap systems (Astral a plus) and/or Agilent Q-TOFs
- Knowledge of cancer pathways.
- Experience with ASMS and APMS workflows (in a drug discovery setting a plus)
Requirements
- Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline
- 2+ years (Ph.D.), 4+ years (M.S.), or 5+ years (B.S.) of relevant industry, academic, or postdoctoral experience
- Strong foundation in mass spectrometry, with hands-on experience operating, troubleshooting, and optimizing LC-MS instrumentation
- Experience developing and implementing mass spectrometry-based analytical, screening, and/or proteomics workflows
- Demonstrated ability to apply mass spectrometry approaches to address biological questions and support drug discovery research
- Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation
- Experience developing and optimizing sample preparation, chromatography, and mass spectrometry methods for biological applications
- Strong data analysis and interpretation skills, with the ability to derive meaningful conclusions from complex mass spectrometry datasets
- Ability to troubleshoot analytical challenges and contribute creative solutions to technical and scientific problems
- Ability to collaborate effectively with scientists across biology, chemistry, and related disciplines to develop fit-for-purpose analytical approaches
- Strong written, verbal, and presentation skills, with the ability to communicate scientific findings to multidisciplinary teams
- Ability to work on-site in San Carlos, CA
Benefits
- Medical, Dental & Vision
- 401(k)
- FSA/HSA
- Life Insurance
- Paid Time Off
- Wellness
- Annual bonus plan
- Discretionary equity awards
- Employee Stock Purchase Plan
Company overview
BeiGene, Ltd., now rebranding as BeOne Medicines, is a global commercial-stage biotechnology company specializing in the discovery, development, manufacturing, and commercialization of innovative oncology medicines. Founded in 2010 by John V. Oyler and Xiaodong Wang, the company has grown into a multinational organization with headquarters in Cambridge, Massachusetts, Beijing, China, and Basel, Switzerland. BeiGene focuses on developing targeted and immune-oncology therapies for cancer treatment, with a diverse pipeline that includes internally discovered products like BRUKINSA (zanubrutinib), a Bruton's tyrosine kinase inhibitor, and Tevimbra (tislelizumab), a PD-1 inhibitor. The company operates across six continents with over 45 countries participating in clinical trials and has enrolled more than 30,000 patients in its research programs. With approximately 12,000 employees worldwide, BeiGene has established itself as a significant player in global oncology, particularly with strong market presence in China and expanding operations in the United States and Europe. The company's mission centers on expanding access to high-quality cancer therapies worldwide through persistent innovation and challenging traditional approaches to drug development.