Senior Scientist - PKDM-BA
Amgen
Summary
The responsibilities of the successful candidate will be to design and execute biological and/or biophysical experiments to understand the ADME properties of large molecule therapeutics (and non-traditional small molecule therapies) in support of both drug discovery and early development programs.
Job description
This is a lab-based role, with an emphasis on assay/technology development for the purposes of defining mechanisms of in vivo clearance and/or biodistribution processes. This role requires an understanding of preclinical ADME and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment.
Other responsibilities include data interpretation and communication of results to project team representatives and electronic laboratory notebook keeping of results. The candidate may also be responsible for developing and executing department strategy for drug candidate teams as a PKDM project representative.
Basic Qualifications
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
- OR Master's degree and 3 years of related experience
- OR Bachelor's degree and 5 years of related experience
Preferred Qualifications
- PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
- 2+ years of protein therapeutics drug discovery and development experience in biotech industry, basic understanding of protein therapeutics pharmacokinetics.
- Expertise, and a strong interest in evaluating protein-protein interactions using modern biophysical analytic techniques.
- Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.
- Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.
- Excellent communication and interpersonal skills and the ability and interest to learn and deliver results in a fast-paced, demanding environment.
Requirements
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
- OR Master's degree and 3 years of related experience
- OR Bachelor's degree and 5 years of related experience
- PhD or MS in immunology, cell biology, biochemistry, biophysics, or equivalent.
- 2+ years of protein therapeutics drug discovery and development experience in biotech industry, basic understanding of protein therapeutics pharmacokinetics.
- Expertise, and a strong interest in evaluating protein-protein interactions using modern biophysical analytic techniques.
- Expertise in protein biochemistry and/or cell biology techniques, including reagent preparation, assay development, optimization and troubleshooting.
- Experience translating biochemical and biophysical observations and phenomena into relevant cellular and animal-based models with mechanistic insights is desirable.
- Excellent communication and interpersonal skills and the ability and interest to learn and deliver results in a fast-paced, demanding environment.
Benefits
- Health Insurance
- Dental Coverage
- Vision Coverage
- Retirement and Savings Plan
- Life Insurance
- Disability Insurance
- Flexible Spending Accounts
- Annual Bonus Program
- Stock-based Long-term Incentives
- Paid Time Off
- Flexible Work Models
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.