Senior Scientist - Precision Oncology
Amgen
Summary
The Oncology Research organization is seeking a highly motivated Senior Scientist to uncover and translate cancer biology that enables the discovery and advancement of novel therapeutic programs. In this role, you will have the opportunity to shape experimental strategy for emerging oncology programs, establish compelling evidence for new therapeutic hypotheses, and define mechanisms that support program progression.
Job description
Working in a highly collaborative research environment, you will partner with multidisciplinary teams across biology, chemistry, computational sciences, pharmacology, and translational sciences to transform biological insight into impactful oncology discoveries.
Key Responsibilities
- Design and execute innovative studies to validate oncology targets, test therapeutic hypotheses, and define mechanisms of action in cancer-relevant models.
- Apply advanced CRISPR genome-editing technologies to establish target function and genetic dependencies.
- Evaluate and apply emerging technologies and AI tools that can accelerate oncology discovery.
- Establish quantitative, fit-for-purpose assays to investigate target engagement, pathway modulation, protein function, protein-complex biology, and small-molecule mechanism of action.
- Analyze and interpret complex data, communicating findings and biological insights to multidisciplinary discovery and leadership teams.
- Collaborate effectively with scientists across the Research organization to solve challenging problems in oncology drug discovery.
Basic Qualifications
- Doctorate degree or Master's degree and 2 years of scientific experience or Bachelor's degree and 4 years of scientific experience
Preferred Qualifications
- Ph.D. in Cancer Biology, Cell Biology, Molecular Biology, Genetics, Chemical Biology, or a related discipline, with 1-3 years of relevant postdoctoral and/or industry research experience.
- Strong background in cancer cell biology, cell signaling, mechanistic pharmacology, and small-molecule oncology drug discovery, with a demonstrated record of scientific impact through first-author publications in high-impact peer-reviewed journals and/or patent inventorship.
- Subject matter expertise in advanced CRISPR technologies and genome engineering.
- Expertise in advanced imaging technologies, including high-content imaging, quantitative microscopy, live-cell imaging, phenotypic imaging, and image-analysis workflows.
- Experience developing and applying high-throughput cellular and biochemical assays, including assay optimization, automation-compatible workflows, quantitative analysis, and rigorous quality control.
- Excellent experimental design, data analysis, troubleshooting, communication, and collaboration skills.
- Demonstrated scientific creativity, innovation, and success in a multidisciplinary research environment.
Requirements
- Doctorate degree or Master's degree and 2 years of scientific experience or Bachelor's degree and 4 years of scientific experience
- Ph.D. in Cancer Biology, Cell Biology, Molecular Biology, Genetics, Chemical Biology, or a related discipline preferred
- 1-3 years of relevant postdoctoral and/or industry research experience preferred
- Strong background in cancer cell biology, cell signaling, mechanistic pharmacology, and small-molecule oncology drug discovery
- Subject matter expertise in advanced CRISPR technologies and genome engineering
- Expertise in advanced imaging technologies including high-content imaging, quantitative microscopy, live-cell imaging, phenotypic imaging, and image-analysis workflows
- Experience developing and applying high-throughput cellular and biochemical assays
- Excellent experimental design, data analysis, troubleshooting, communication, and collaboration skills
Benefits
- Health Insurance
- Dental Coverage
- Vision Coverage
- Retirement and Savings Plan
- Life Insurance
- Disability Insurance
- Flexible Spending Accounts
- Annual Bonus Program
- Stock-Based Long-Term Incentives
- Paid Time Off
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.