Senior Scientist - siRNA Therapeutics
Amgen
Summary
Join the Genetic Medicines team in Thousand Oaks, CA. As a new member of this team, you will be responsible for generating and implementing novel methods to deliver RNA-based therapies to previously unreachable cellular destinations across Amgen's therapeutic areas.
Job description
What you will do
Join the Genetic Medicines team in Thousand Oaks, CA. As a new member of this team, you will be responsible for generating and implementing novel methods to deliver RNA-based therapies to previously unreachable cellular destinations across Amgen's therapeutic areas.
Key Responsibilities
- Help identify and implement new technologies to accelerate discovery at the leading edge of targeted delivery
- Generate and bring to life new approaches for realizing how extrahepatic RNA therapeutics can be deployed
- Collaborate closely with disease area, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert
- Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums
Basic Qualifications
- Doctorate degree PhD OR PharmD
- Or Master's degree and 2 years of relevant scientific experience
- Or Bachelor's degree and 4 years of relevant scientific experience
Preferred Qualifications
- PhD or Master's in molecular biology, cell biology, RNA biology or a related discipline, with relevant industry or equivalent research experience in oligonucleotide therapeutics and/or genetic medicines
- Experience performing high-throughput cell-based screening and generating sequencing-based screening data using methods such as Drug-seq, including sample preparation and quality control
- Experience designing and executing studies of extrahepatic siRNA delivery using antibody-siRNA conjugates and other delivery modalities, including in vivo study design, execution, sample processing and data interpretation
- Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant scientific contributions
- Ability to serve as a subject matter expert and representative on cross-functional project teams: communicate data and recommendations clearly, coordinate with one or more therapeutic areas, and translate project questions into experimental plans
Requirements
- Doctorate degree PhD OR PharmD
- Or Master's degree and 2 years of relevant scientific experience
- Or Bachelor's degree and 4 years of relevant scientific experience
- PhD or Master's in molecular biology, cell biology, RNA biology or a related discipline
- Relevant industry or equivalent research experience in oligonucleotide therapeutics and/or genetic medicines
- Experience performing high-throughput cell-based screening
- Experience generating sequencing-based screening data using methods such as Drug-seq
- Sample preparation and quality control experience
- Experience designing and executing studies of extrahepatic siRNA delivery using antibody-siRNA conjugates
- In vivo study design, execution, sample processing and data interpretation
- Demonstrated track record of independent critical thinking, complex problem solving, and innovative research
- Ability to serve as a subject matter expert on cross-functional project teams
- Clear communication of data and recommendations
- Ability to translate project questions into experimental plans
Benefits
- Health Insurance
- Dental Coverage
- Vision Coverage
- Life Insurance
- Disability Insurance
- Retirement and Savings Plan
- Flexible Spending Accounts
- Annual Bonus Program
- Stock-Based Long-Term Incentives
- Paid Time-Off
Company overview
Amgen Inc. is a leading American multinational biopharmaceutical company headquartered in Thousand Oaks, California, founded in 1980. As one of the world's largest independent biotechnology companies, Amgen specializes in discovering, developing, manufacturing, and delivering innovative human therapeutics. The company focuses on six key therapeutic areas: inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience. Amgen's portfolio includes blockbuster drugs such as Enbrel for autoimmune diseases, Prolia and XGEVA for osteoporosis, Repatha for cholesterol management, Otezla for psoriasis, and Neulasta for chemotherapy-induced neutropenia. With approximately 28,000 employees worldwide, Amgen operates as a component of both the Dow Jones Industrial Average and Nasdaq-100 indices. The company maintains a robust research and development pipeline with numerous clinical programs across various stages, leveraging cutting-edge biotechnology and human genetic data to address some of the world's most challenging diseases. Amgen's manufacturing capabilities span multiple global locations, and it distributes products through pharmaceutical wholesale distributors and direct-to-consumer channels.