Senior Scientist, Targeted Delivery Biology

Position Responsibilities

• Design and apply mechanistic and functional assays to interrogate nanoparticle delivery across key biological barriers, from cellular uptake and endosomal escape to functional payload activity, and translate findings into actionable design principles that guide nanoparticle optimization and next-generation delivery strategies.
• Establish cell-based approaches to identify and validate receptors for targeted delivery, investigating key receptor properties, including expression, accessibility, internalization kinetics, and trafficking, to optimize delivery efficiency and selectivity.
• Contribute to internal and external efforts in receptor identification and targeting-ligand discovery and development to enable targeted delivery into new cell types and tissues.
• Develop and apply in vitro safety and biocompatibility assays to characterize biological responses to nanoparticle delivery systems and support early identification and mitigation of delivery-related liabilities.
• Contribute to the evaluation and assessment of emerging delivery technologies, applying delivery-relevant biological and functional criteria to support platform and lead selection decisions.
• Collaborate effectively across multidisciplinary teams, including formulation and delivery sciences, protein engineering, analytical development, and pharmacology, to translate biological insights into improved delivery platform design.
• Effectively communicate scientific findings and actionable recommendations to multidisciplinary teams and leadership to influence delivery strategy and program decisions.
• Provide scientific mentorship to junior scientists and contribute to the development of new experimental approaches and technologies.

Basic Qualifications

• Bachelor’s Degree 7+ years of academic and / or industry experience
• Or Master’s Degree 5+ years of academic and / or industry experience
• Or Ph.D. or equivalent advanced degree in the Life Sciences 2+ of academic and / or industry experience

Preferred Qualifications

• PhD in Cell Biology, Molecular Biology, Immunology, Biochemistry, Bioengineering, Pharmaceutical Sciences, or a related discipline with 2+ years of relevant industry experience; or MS with 5+ years; or BS with 7+ years of relevant experience.
• Strong background in cell biology and quantitative cell-based assay development, with demonstrated ability to design and apply experiments to address mechanistic biological questions.
• Strong understanding of receptor-mediated delivery, including the key properties that influence productive cellular uptake and delivery.
• Experience developing and applying quantitative and functional cell-based assays across a range of imaging, flow cytometry, molecular biology, and biochemical methods.
• Experience with nanoparticles, lipid nanoparticles, liposomes, extracellular vesicles, biologics, nucleic acid delivery systems, antibody-drug conjugates, or other complex delivery modalities is preferred.
• Demonstrated ability to work effectively in multidisciplinary teams and thrive in a highly collaborative, cross-functional research environment.
• Strong scientific communication skills, with the ability to present complex data and mechanistic insights clearly and compellingly to diverse audiences including project teams and senior leadership.