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Senior Software Engineer

Tempus AI

Chicago, ILOnsitePosted 19 days ago$110,000 - $160,000
Full TimeSenior LevelTech & Data (Health IT)AI Biotech
Original posting ↗

Summary

We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives. In this role, you will lead the analysis and design of complex technical problems, architect robust systems, and mentor emerging talent. This position requires deep expertise in full-stack engineering, relational data systems, bioinformatic workflow orchestration, and algorithmic development. As a senior technical leader, you will be expected to craft high-quality code, scale genomic data processing pipelines, leverage modern AI tooling, integrate APIs into user-facing applications, and embed agentic workflows into our core product ecosystem.

Job description

About the Role

We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives. In this role, you will lead the analysis and design of complex technical problems, architect robust systems, and mentor emerging talent. This position requires deep expertise in full-stack engineering, relational data systems, bioinformatic workflow orchestration, and algorithmic development. As a senior technical leader, you will be expected to craft high-quality code, scale genomic data processing pipelines, leverage modern AI tooling, integrate APIs into user-facing applications, and embed agentic workflows into our core product ecosystem.

Technical Requirements

  • 5+ years of advanced TypeScript/JavaScript/python development with a deep understanding of language features and optimization techniques.
  • Extensive experience architecting and leading development with Node.js and NestJS frameworks.
  • Experience with React development with a demonstrated ability to design and implement complex component systems.
  • Proven experience building, scaling, and maintaining bioinformatics orchestration pipelines for high-throughput genomic data analysis using workflow frameworks such as Nextflow.
  • Hands-on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower) across cloud environments.
  • Hands-on experience leveraging GenAI coding tools and autonomous agents (e.g., Copilot, Cursor, LLM APIs) to accelerate development, refactor codebases, and auto-generate comprehensive unit/integration tests.
  • Experience or strong working knowledge of integrating APIs and GenAI technologies into production applications.
  • Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning.
  • Proven expertise implementing sophisticated Redis caching solutions for high-throughput systems.
  • Demonstrated success designing and implementing distributed microservice architectures that seamlessly interface with data-intensive bioinformatic workflows.
  • Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines and cloud-based compute backends for pipeline execution.
  • Mastery of enterprise-level design patterns and their practical application in large-scale, mission-critical systems.

What Makes You a Great Fit

  • 7+ years of software development experience with a track record of technical leadership.
  • Ability to make high-impact architectural decisions that balance business needs, data infrastructure constraints, and scientific computing requirements.
  • Track record of bridging the gap between software engineering and computational biology/bioinformatics teams to streamline workflow execution and data delivery.
  • Enthusiasm for championing AI-assisted development practices, driving adoption of agentic workflows, and mentoring teams through the evolving landscape of AI tools.
  • History of successfully delivering complex projects in fast-paced environments.
  • Strong communication skills with experience presenting technical solutions to diverse stakeholders.
  • Proven ability to drive cross-team technical initiatives and resolve complex engineering challenges.

Bonus Points

  • Advanced expertise in Nextflow (DSL2) custom module/subworkflow development and integration with cloud-native storage/compute engines (e.g., GCP Batch, Life Sciences API, or AWS Batch).
  • Experience with search technologies such as Elasticsearch or OpenSearch.
  • Experience with containerization orchestration (Docker, Kubernetes).
  • Background in biotech, genomics, or precision medicine.

Requirements

  • 5+ years of advanced TypeScript/JavaScript/python development
  • Extensive experience architecting and leading development with Node.js and NestJS frameworks
  • Experience with React development
  • Proven experience building, scaling, and maintaining bioinformatics orchestration pipelines using Nextflow
  • Hands-on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower)
  • Hands-on experience leveraging GenAI coding tools and autonomous agents
  • Experience integrating APIs and GenAI technologies into production applications
  • Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning
  • Proven expertise implementing sophisticated Redis caching solutions
  • Demonstrated success designing and implementing distributed microservice architectures
  • Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines
  • Mastery of enterprise-level design patterns
  • 7+ years of software development experience with a track record of technical leadership
  • Ability to make high-impact architectural decisions
  • Track record of bridging the gap between software engineering and computational biology/bioinformatics teams
  • Enthusiasm for championing AI-assisted development practices
  • History of successfully delivering complex projects in fast-paced environments
  • Strong communication skills
  • Proven ability to drive cross-team technical initiatives

Benefits

  • Incentive compensation
  • Restricted stock units
  • Medical benefits

Company overview

Tempus AI, Inc. (NASDAQ: TEM) is a pioneering healthcare technology company founded in 2015 by Eric Lefkofsky in Chicago, Illinois. The company was established after Lefkofsky's wife was diagnosed with breast cancer, driving his mission to revolutionize cancer care through technology and artificial intelligence. Tempus specializes in applying AI to advance precision medicine by collecting and analyzing vast amounts of molecular, clinical, and genomic data. The company operates across multiple therapeutic areas including oncology, cardiology, radiology, neurology, psychiatry, and dermatology. Tempus provides comprehensive diagnostic services including next-generation sequencing (NGS), PCR profiling, and molecular pathology testing. Its AI-powered platform enables physicians to make real-time, data-driven decisions for personalized patient care and targeted therapies. The company went public in June 2024 and has expanded globally with operations in multiple countries. Tempus continues to innovate at the intersection of healthcare and artificial intelligence, aiming to ensure patients receive the right treatments at the right time for improved health outcomes.

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